Nanofibers Approach for Gastro Retentive Cancer

Gastric cancer is the world's second leading cause of cancer-related death. Due to inadequate drug release and limited residence time at the absorption site, traditional oral dose forms have poor/low bioavailability. GRDDS is particularly useful for increasing the bioavailability of medications with a narrow absorption window in the gastrointestinal tract and for treating local diseases. Polymeric nanofibers have sparked a lot of attention among the numerous nanomaterials used in high-tech applications because of their simplicity of production, controlled size/shape, and characteristics. Filtration, barrier fabrics, wipes, personal care, and biological and pharmaceutical applications have been intensively researched with polymeric nanofibers. Electrospun polymeric nanofibers have recently been demonstrated to be a promising approach for drug delivery systems. The nanofiber method allows for stomach-specific drug release for a more extended period and improves local drug action due to the drug's extended contact time with the gastric mucosa. As a result, nanofiber technology appears to be a promising strategy for gastric retention drug delivery systems. 

Keywords: Bio-adhesive System, Drug Delivery System, Electrospun Technology, Floating System, Gastroretentive Cancer, GIT, GRDDS, Nanofibers, Non-floating System, Stomach, Swelling System.