Animal Models used in Cancer Research: Role of Transgenic Animals

In spite of the existence of many chronic diseases, cancer is still one of the major distresses for public health and is also the second largest major concern of death. The data collected from the last 50 years of research showed that very few cancers are curable, and the fear factor related to this disease is still unaltered. Victorious bench-tobedside transformation of basic methodical findings about cancer into therapeutic involvements for patients relies on the appropriate selection of animal experimental models. Animal models play an important role in studying the genetics and biology of human cancers as well as the preclinical examination of various cancer therapeutics and cancer prevention. In this chapter, we will review the imperative animal models such as spontaneous tumour models, chemically induced tumour models, radiationinduced tumour models, etc., along with other animal models, such as porcine, canines, etc., used for immuno-oncological research. In addition, the role of transgenic animals in cancer research will also be discussed.

Keywords: Adenoviruses, Animal models, Cancer, Canines, Fishes, Herpesviruses, Porcines, Spontaneous tumour models, Transgenic animal models.