New Findings from Natural Substances

LC-HR-MS Based Approach to Identify Triterpenes in Astragalus Species

Author(s): Nilufar Z. Mamadalieva* and Hidayat Hussain

Pp: 116-132 (17)

DOI: 10.2174/9789815051421122010008

* (Excluding Mailing and Handling)


Astragalus genus has been recorded as yielding a wide range of flavonoids, triterpenes, triterpene saponins, and polysaccharides. Cycloartane- and oleanane-type triterpenes are widely distributed in this genus with intriguing biological effects. Combining liquid chromatography (LC) with high-resolution mass spectrometry (HRMS) has provided a valuable tool in the analysis of these triterpenes in plants. In this chapter, we summarized the main triterpenes studied by liquid chromatography highresolution mass spectrometry (LC-HR-MS) associated with mass analysers, molecular weight information and mass fragmentation, presenting an interesting overview of increasing interest for cycloartane- and oleanane-type triterpenes.

Keywords: Astragalus, Biological activity, Chromatography, Fragmentation, Triterpenes, Orbitrap, LC-HR-MS, QTOF-MS.

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