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DOI: 10.2174/97816080572451130101 eISBN: 978-1-60805-724-5, 2013 ISBN: 978-1-60805-725-2
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For Books Alexander B. Poletaev , " Physiologic Autoimmunity and Preventive Medicine ", Bentham Science Publishers (2013). https://doi.org/10.2174/97816080572451130101
Print ISBN978-1-60805-725-2
Online ISBN978-1-60805-724-5
Page: i-vii (7) Author: Oleg V. Grinko DOI: 10.2174/9781608057245113010001
Page: viii-xi (4) Author: Alexander B. Poletaev DOI: 10.2174/9781608057245113010002
Page: xii-xiii (2) Author: Alexander B. Poletaev DOI: 10.2174/9781608057245113010003
Page: 3-20 (18) Author: Alexander B. Poletaev DOI: 10.2174/9781608057245113010004 PDF Price: $30
Page: 21-45 (25) Author: Zlatko Dembić DOI: 10.2174/9781608057245113010005 PDF Price: $30
Page: 46-71 (26) Author: Olga M. Moiseeva, D.A. Grigoŕeva and Sergey V. Skurydin DOI: 10.2174/9781608057245113010006 PDF Price: $30
Page: 72-166 (95) Author: Leonid P. Churilov, Yury I. Stroev and Albert Sh. Zaichik DOI: 10.2174/9781608057245113010007 PDF Price: $30
Page: 167-198 (32) Author: Anastasiya Putintseva, Sergey Krynskii, Mariya Bocharova, Anna Andreeva, Mathew von Herrath, Dmitrii Kostyshev, Iliya Kurguzov, Paul Muchowski, Artem Kostyakov, Michail Paltsev and Sergey Suchkov DOI: 10.2174/9781608057245113010008 PDF Price: $30
Page: 199-207 (9) Author: Alexander B. Poletaev DOI: 10.2174/9781608057245113010009 PDF Price: $30
Page: 208-233 (26) Author: Leonid P. Churilov, Yury I. Stroev, Irina Yu. Serdyuk and Oksana M. Mudzhikova DOI: 10.2174/9781608057245113010010 PDF Price: $30
Page: 234-238 (5) Author: Alexander B. Poletaev DOI: 10.2174/9781608057245113010011
The book is dedicated to the history and current status of physiologic autoimmunity concept and relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. The main forms of physiological activity of the immune system are based on the intrinsic abilities of self-identification, self-maintenance, self-regulation, and self-reparation — that is recognizing components of the “self ”, i.e. natural autoimmunity. The most ancient and homeostatically important functions of natural autoimmunity are autoclearance as well as construction and support of multicellularity. A considerable number of immune functions, including those related to antimicrobial defense, derive from these basic ones. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonines), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the aff ected organ. This phenomenon is sanogenic in nature and adaptive in essence. Therefore, secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. In relation to experimental production and clinical reveal of antibodies towards nuclear antigens, penetrating into living cell nuclei and altering nuclear acid synthesis, cell proliferation and function, autoantibodies can be regarded as hormone-like bioregulators of gene expression. Apparently, immune system is able to reproduce complementary regulators for various cell receptors, including nuclear ones. Book is unique, it is a single monograph comprehensively including history and current status of natural autoimmunity problem. It describes a fundamental concept essencial for every branch of Medicine and Pathology. The concept described has broad practical application for Health Care, because it establishes effective method of early prediction for many different diseases, creates a basis for prophylaxis. Reader has a chance to get rid of old dogmas and acquire new instrument for fruitful theoretical reasoning, research planning and predictive/preventive practical medical work.
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