Fetal Alcohol Spectrum Disorders (FASD) are life long and do not disappear with maturity. As children who have been exposed prenatally reach pubescence, they will experience the typical physical and emotional issues associated with adolescence. Navigating the rocky waters of adolescence is particularly challenging to individuals whose developmental abilities are significantly less than what is expected of them according to their chronological age. In many instances, physical, psychological, behavioral and social problems become more serious and continue on into adulthood for those with FASD. Lifespan issues considered in this chapter are: routine health care; safety; sleep; oral and dental care; nutrition and fitness; sexuality; sexual abuse; work; and co-occurring disorders. Practical considerations are also suggested.