Overweight and obesity are risk factors for type 2 diabetes, and they also
influence the overall prognosis. Almost 90 % of type 2 diabetic subjects are overweight
and more than half are obese. Type 2 diabetes is a progressive metabolic disorder
conferring an increased risk of cardiovascular comorbidities, including hypertension,
coronary artery disease and stroke. The availability of several different classes of
antidiabetic drugs in the last few years has increased the number of choices for
physicians. The aim of these therapies is to reduce and maintain glucose concentrations
and thereby prevent development of complications. When choosing between different
antidiabetic drugs attention should be paid to their effect on body weight too.
Keywords: Adipose tissue, antidiabetic, BMI, bromocriptine, carbohydrate,
colesevelam, complication, diabetes, DPP4 inhibitors; gastrointestinal, glinides,
GLP-1 receptor agonists, HbA1c, hypoglycemia, hypothalamus, insulin, kidney,
metabolism, metformin, obesity, pramlintide, SGLT2 inhibitors, sulfonylurea,
thiazolidinedione.