Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
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Cite this chapter as:Arto Liljeblad, Annukka Kallinen, Liisa T. Kanerva ;
Biocatalysis in the Preparation of the Statin Side Chain, Advances in Organic Synthesis (2013) 3: 195. https://doi.org/10.2174/9781608054688113030008
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