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Advances in Organic Synthesis

Volume: 3

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Biocatalysis in the Preparation of the Statin Side Chain

Author(s): Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva

Pp: 195-236 (42)

DOI: 10.2174/9781608054688113030008

* (Excluding Mailing and Handling)

Abstract

Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

Keywords: Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nirilase, aldolase.

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