Palladium(0)-catalyzed allylation of soft nucleophiles is a powerful synthetic
methodology for the construction of carbon-carbon or carbon-heteroatom bond. The
possibility of controlling the regioselectivity is one of the most interesting aspects of
this chemistry. In this review, the different factors that can affect the regiochemistry of
the nucleophilic attack will be discussed.
Keywords: Palladium, allylic substitution, regioselectivity, soft nucleophiles, ligands,
steric effects, electronic effects, allylation, alkylation, amination, pi-allylpalladium
complexes, carbon-carbon bond formation, carbon-heteroatom bond formation.
