Advances in Organic Synthesis

Volume: 2

Synthesis of Chiral Fluorinated Materials via Biotransformation

Author(s): Tomoya Kitazume, Tomoko Matsuda and Kaoru Nakamuraa

Pp: 463-490 (28)

DOI: 10.2174/978160805198410602010463

* (Excluding Mailing and Handling)


Biotransformation of organofluorine materials into the optically active functionalized fluorinated materials along with the discussion on the effect of fluorine atom(s) during the enantioselective and/or diastereoselective transformations is described. The ability of microorganism to discriminate between enantiomers is very important for the purpose of resolution and asymmetric synthesis. Also included are discussions on recent developments in methodologies to control enantioselectivities of catalytic reactions. Examples of practical applications that involve reduction of various types of ketones are also included.

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