Nanotherapeutics for the Treatment of Hepatocellular Carcinoma

Pp: 219-247 (29)

* (Excluding Mailing and Handling)

Currently, hepatocellular carcinoma (HCC) is the third leading cause of

mortality among cancerous diseases. It is a primary type of liver cancer possessing

unique features like solid malignant tumor type growth, leaky vasculature, and

angiogenesis. The success of conventional treatment in the management of HCC is

constrained due to unresponsiveness to particular approaches, drug resistance, systemic

side effects, and recurrence of malignancy. The development of nanotherapeutics offers

an impending key for overcoming these challenges. Nanotherapeutics utilizes

nanosized or nanostructured materials to attain particular therapeutic and

pharmacokinetic purposes. The diverse targeting strategies and site-specific drug

release patterns of this approach enlighten the hope for effective management of HCC.

Scientists have developed several nanomaterials like nanoparticles, nanogel, and

liposomes to deliver chemotherapeutic agents specifically to HCC sites with improved

efficacy, safety, and selectivity. Active targeting has remained most common and

effective in HCC management among active, passive, and stimuli-responsive targeting

strategies. Hopefully, some nanoformulations for HCC treatment have proved their

promising effects in clinical trials. In this chapter, an attempt is made to illustrate the

overview of HCC, the impact of nanotherapeutics, along with recent developments,

suitability, and challenges of various nanotherapeutic approaches for HCC

management.

Keywords: Chemotherapy, Hepatocellular carcinoma, Nanomedicine, Nanoparticles, Primary cancer, Nanotheranostic, Selectivity, Targeting.

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