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Physiopathogenesis of Hematological Cancer

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Transcription Factors in Hematological Malignancies

Author(s): Estela Maria Novak and Durvanei Augusto Maria

Pp: 78-102 (25)

DOI: 10.2174/978160805259211201010078

* (Excluding Mailing and Handling)

Abstract

Transcription factors are key regulators of the pattern of gene expression in a cell and directly control central processes such as proliferation, survival, self-renewal, and invasion. Alterations in the mechanisms that normally control these functions can lead to hematological malignancies. This chapter will describe the highlights of the main transcription factors in hematological malignancies.

Keywords: Hypoxia-Inducible Factors (HIF-1), Nuclear Factor-κB (NF-κB), Signal Transducer and Activator of Transcription (STAT), Homeobox (HOX), Lymphoma, Myelodysplastic Syndromes, Leukemia, NUP98-HOXA9, Multiple Myeloma, Therapeutic Strategies.

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