Globally, cardiovascular disease is one of the predominant clinical conditions, which accounts for about 50% of human mortality and morbidity. No doubt pharmacological and surgical interventions have dramatically improved the quality of life of patients with cardiovascular diseases. However, the demand for new therapeutic interventions as well as regenerative strategies is currently increasing. Biomaterials, both natural and synthetic, have exhibited great potential in cardiac regenerative therapy. Therefore, the development of biomaterials based extracellular matrix, grafts or stents, etc. would be highly beneficial for supporting the natural function and physiology of heart tissues.