The novel coronavirus disease 2019 (COVID-19) is an acute infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). After severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS), COVID-19 is the third acute infectious disease caused by the coronavirus in humans. According to WHO, as of 3rd March 2020, the mortality rate of COVID-19 cases was reported globally as approximately 3.4% and it was observed particularly in patients who were suffering from comorbid conditions. The exact mechanism of death is unclear so far, however, emerging reports have indicated that less oxygen supply, excessive release of cytokines, and inflammatory mediators could be one of the reasons. Thus, in this chapter, we have provided classification of death cases occurring due to COVID-19. The possible mechanism of death is also discussed. The last section of the chapter discusses the role of concomitant medication in the death of COVID-19 patients.