Angiogenesis is a vital step for complete organ engineering, and the
microenvironment is one of the four basic elements of tissue engineering.
Microenvironment factors such as oxygen content and stress are key dynamic factors
that can trigger the variations of angiogenesis. We may induce the formation of
beneficial blood vessels and prevent the formation of pathological blood vessels by
precisely regulating the microenvironment. In this chapter, we will elaborate the
interaction between vascular endothelial cells and the extracellular microenvironment
and summarize the influence of various microenvironment factors on angiogenesis. The
finding that microenvironment factors play such a concerted role in angiogenesis
suggests that incorporating microenvironment factors into tissue engineering might
accelerate the development of novel therapeutics.
Keywords: Angiogenesis, Endothelial cell, Extracellular matrix,
Microenvironment, Stiffness.
