The Human Papillomavirus (HPV) vaccines have been widely introduced in
the national immunization programs of the medium and high income countries. Both
bivalent and quadrivalent vaccines are generally known as safe and well-tolerated. Site
injection symptoms are the most frequent adverse events reported. Among them, pain
was generally the most frequently referred local symptom. It was shown that the
occurrence of serious adverse events was similar in both vaccine and control groups.
Regarding to the reports, no deaths from the introduction of the two vaccines have been
attributed to HPV vaccination. Studies on the safety of the vaccine in some populations
(men, women older than 25 years, HIV+ girls) have given satisfactory results. However,
there are some unresolved issues in the current HPV vaccines for different populations
such as safety and duration of protection, cross-protection, tolerability, and side effects
(e.g., pain, swelling and redness, autoimmune and neurological conditions) similar to
other vaccines. Briefly, we explain the possible adverse effects of common HPV
vaccines in this chapter.
Keywords: HPV, Side effects, Vaccine.