The induction of immunotolerance of the host's immune system by the
persistent infection of HPV is one of the most important mechanisms for cervical
lesions. The immune system modifications induced by HPV infection include tumorassociated
macrophage differentiation, a compromised cellular immune response, an
abnormal imbalance between type 1 T-helper cells (Th1) and Th2 cells, regulatory T
cell infiltration, and down-regulated DC activation. In this chapter, the effects of HPV
and its mechanism of action will be discussed on immune system.
Keywords: Adaptive immune system, HPV, Immunobiology, Innate immune
system.Adaptive immune system, HPV, Immunobiology, Innate immune
system.
