HPV Infections: Diagnosis, Prevention, and Treatment

Immunity against HPV-Related Cancers

Author(s): Afshin Khavari, Kimia Kardani and Azam Bolhassani

Pp: 95-119 (25)

DOI: 10.2174/9781681086170118010010

* (Excluding Mailing and Handling)


The induction of immunotolerance of the host's immune system by the persistent infection of HPV is one of the most important mechanisms for cervical lesions. The immune system modifications induced by HPV infection include tumorassociated macrophage differentiation, a compromised cellular immune response, an abnormal imbalance between type 1 T-helper cells (Th1) and Th2 cells, regulatory T cell infiltration, and down-regulated DC activation. In this chapter, the effects of HPV and its mechanism of action will be discussed on immune system.

Keywords: Adaptive immune system, HPV, Immunobiology, Innate immune system.Adaptive immune system, HPV, Immunobiology, Innate immune system.

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