Human papillomavirus (HPV)-associated cancers include cervical cancer,
vulvar cancer, penile cancer, vaginal and anal cancer and a subset of head and neck
cancers. Thus, effective vaccination against HPV infection is recommended to decrease
their incidence and progression in the world. The FDA of the USA has approved two
preventive vaccines to inhibit the spread of HPV. However, preventive vaccines do not
exert therapeutic effects on pre-existing HPV infections, so therapeutic vaccines are
being developed to generate a cell-mediated immune response to infected cells. HPV
vaccination might be useful not only for prevention of cervical cancer, but also for the
reduction of other related cancers. Herein, HPV-related cancers will be explained to
consider their preventive and therapeutic pathways in future.
Keywords: Cancer, Genital warts, Infection, HPV, Pathogenesis.
