The infra-sellar and nasopharyngeal craniopharyngiomas (CPs) were the special type, which predominantly presented in the children. In this chapter, we briefly depicted the clinical features of this type of tumor. Patients suffered with this type of CP were rarely more than 16 years old. The pathology was all adamantous tumor. As concerned to the clinical manifestation, except the pituitarism, growth retardation, and optical pathway injury, the pediatric patients always suffered with rhinocleisis, homorrhinia and airway obstruction. As extensive involvement, it was quite difficult to radical remove the tumor. As the result, tumor recurrent caused poor quality of life. Until now, the best treatment strategy was still missing.