COVID-19: Current Challenges and Future Perspectives informs readers about the current status of knowledge on COVID-19 infection. The book begins by presenting basic information about the history, epidemiology, pathogenesis, diagnosis, treatment and preventive measures against COVID-19. The second part of the book contains information about the repurposing of drugs, herbal medicines, and immunotherapy against COVID-19 infections. Integrating both general and advanced information about Sars-cov-2, this book updates a wide range of readers including students, researchers (virologists, pharmacologists), health care professionals (physicians, nurses, pharmacists, paramedics) and the general public on novel coronaviruses and COVID-19.

This monograph presents information about the history and evolution of tuberculosis treatment, and the potential of the benzothiazole moiety for anti-tuberculosis (anti-TB) activity. The book introduces the reader to basic information about benzothiazole as a drug candidate before delving into the anti-tubercular properties of derivative compounds in subsequent chapters. The contributors explain quantitative structural-activity relationships of benzothiazole with anti-TB activity along with the importance of in-silico (computer aided) techniques in the drug design process. This is followed by a chapter which details Mycobacterium tuberculosis biology, strains as well as symptoms of tuberculosis infections. The book then explains in-vitro and in-vivo methods used to evaluate drug efficacy against tuberculosis along with the synthesis and anti-TB activity of the benzothiazole derivatives (benzothiazole diamide, benzothiazole guanidinyl derivatives and benzothiazole conjugated pyrazole derivatives). This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.

The Coronavirus Disease 2019 (COVID-19) pandemic has affected almost every part of the globe with millions of cases and over a million deaths. The pandemic has had a significant global economic impact and addressing it systematically requires significant efforts from researchers, healthcare workers and governments. The COVID-19 Pandemic covers relevant aspects of this viral pandemic including information about the SARS-CoV-2 pathogen (morphology, genome, proteins, structural protein genes, replication), global epidemiology, transmission, risk factors, clinical manifestation, management, host immune response, pathogenesis, diagnosis and therapeutic agents (antivirals, natural compounds and vaccines). Readers will find basic and advanced knowledge about the disease organized into simple and easy-to-read chapters about the disease, making this book a handy and comprehensive reference for general readers, academics and biology students, alike.

Both Asia and Africa are home to many plants that can be used for the treatment of many diseases and their medicinal properties are gaining interest in western societies. Medicinal plants from Asia and Africa are used for their healing abilities and also have a symbolic meaning in communities. The importance of traditional autochthonous plant remedies plays a crucial role in the health of millions of people of these two continents. Even today, traditional medicine represents the dominant medical system for millions of people showing a significant impact on health care practices. Therefore, traditional operators still represent a vital part of regional healthcare systems. For this reason, pharmaceutical industries consider traditional medicine as a source for the identification of bioactive compounds that can be used in the preparation of synthetic drugs. Biologically Active Natural Products from Asia and Africa: A Selection of Topics guides the reader to information about new natural products from these regions and the different ways to use them to treat or alleviate many of the most common diseases. The volume presents nine topics covering a number of facets of natural product medicine including: - pharmaceutical analysis of anti-diabetic herbal medicines from Bangladesh and local retailers - caffeine intake and the risk of female infertility - pharmaceutical analysis of Urena sinuata (bur mallow) - anti-CHIKV activities of diterpenes and their derivatives - anti-inflammatory nanogel for the treatment of psoriasis - antlithiatic properties of Moroccan medicinal plants - ethnobotanic, phytochemical and biological activities of Aristolochia longa L. (pipevine) - wound healing potential of combined extracts of stem bark and leaves of sphenocentrum jollyanum (an African shrub) This is a handy reference for specialists and R&D experts in pharmaceutical chemistry who wish to be informed about current knowledge on developing natural remedies in Asia and Africa

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the book series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research. The fifth volume of this series features 5 chapters that cover these topics: - Clinical Eradication of Latent HIV Reservoirs: Where Are We Now? - HIV-1 Genotypic Drug Resistance Testing and Next-Generation Sequencing - Current and Promising Multiclass Drug Regimens and Long-Acting Formulation Drugs in HIV Therapy - Role of Nanotechnology in HIV Diagnosis and Prognosis - Preventive and Therapeutic Features of Combination Therapy for HIV

Herbal Medicine: Back to the Future compiles expert reviews on the application of herbal medicines (including Ayurveda, Chinese traditional medicines and alternative therapies) to treat different ailments. The book series demonstrates the use of sophisticated methods to understand traditional medicine, while providing readers a glimpse into the future of herbal medicine. This volume presents reviews of plant based therapies useful for treating different infectious diseases. The list of topics includes some niche reviews in this area including a review of the neem plant, the historical use of herbs in infectious disease therapy in Russia, and natural remedies from garlic, among other topics., The topics included in this volume are: - Improving anti-microbial activity of allicin and carvacrol through stabilized analogs and nanotechnology - Plant phenolics as an alternative source of antimicrobial compounds - Herbal medicine in Russia’s history: the use of herbal medicine for infectious diseases in Russia’s history - Azadirachta indica (neem) in various infectious diseases - Contribution of novel delivery systems in the development of phytotherapeutics This volume is essential reading for all researchers in the field of natural product chemistry and pharmacology. Medical professionals involved in internal medicine who seek to improve their knowledge about herbal medicine and alternative therapies for tropical and other infectious diseases will also benefit from the contents of the volume.