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DOI: 10.2174/97898114946351210101 eISBN: 978-981-14-9463-5, 2021 ISBN: 978-981-14-9461-1
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For Books Mahesh Bhat, S. L. Belagali , " In-Silico and In-Vitro Approaches to Screen the Antituberculosis Activity of Benzothiazole Analogs ", Bentham Science Publishers (2021). https://doi.org/10.2174/97898114946351210101
Print ISBN978-981-14-9461-1
Online ISBN978-981-14-9463-5
Page: i-i (1) Author: B. Shivarama Holla DOI: 10.2174/9789811494635121010001
Page: ii-iii (2) Author: Mahesh Bhat DOI: 10.2174/9789811494635121010002
Page: iv-iv (1) Author: Mahesh Bhat and S.L. Belagali DOI: 10.2174/9789811494635121010003
Page: 1-18 (18) Author: Mahesh Bhat, S.L. Belagali, B. Manohara and B.K. Sagar DOI: 10.2174/9789811494635121010004 PDF Price: $15
Page: 19-43 (25) Author: Mahesh Bhat, S.L. Belagali and E.V. Sekhar DOI: 10.2174/9789811494635121010005 PDF Price: $15
Page: 44-65 (22) Author: Mahesh Bhat, S.L. Belagali, B. Manohara and S.V. Mamatha DOI: 10.2174/9789811494635121010006 PDF Price: $15
Page: 66-76 (11) Author: Mahesh Bhat and S.L. Belagali DOI: 10.2174/9789811494635121010007 PDF Price: $15
Page: 77-89 (13) Author: Mahesh Bhat and S.L. Belagali DOI: 10.2174/9789811494635121010008 PDF Price: $15
Page: 90-107 (18) Author: Mahesh Bhat and S.L. Belagali DOI: 10.2174/9789811494635121010009 PDF Price: $15
Page: 108-116 (9) Author: Mahesh Bhat and S.L. Belagali DOI: 10.2174/9789811494635121010010
This monograph presents information about the history and evolution of tuberculosis treatment, and the potential of the benzothiazole moiety for anti-tuberculosis (anti-TB) activity. The book introduces the reader to basic information about benzothiazole as a drug candidate before delving into the anti-tubercular properties of derivative compounds in subsequent chapters. The contributors explain quantitative structural-activity relationships of benzothiazole with anti-TB activity along with the importance of in-silico (computer aided) techniques in the drug design process. This is followed by a chapter which details Mycobacterium tuberculosis biology, strains as well as symptoms of tuberculosis infections. The book then explains in-vitro and in-vivo methods used to evaluate drug efficacy against tuberculosis along with the synthesis and anti-TB activity of the benzothiazole derivatives (benzothiazole diamide, benzothiazole guanidinyl derivatives and benzothiazole conjugated pyrazole derivatives). This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.
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