Clinically, personalized medicine also referred to as precision medicine is a
new medical model to be directly tailored for the care of individual patients. It is often
called "the right treatment for the right person at the right time." Most successful
examples of personalized treatments require a rational clinical genomic analysis.
Following Research and Development (R&D) of techniques and analysis of clinical
genomic expression, genomic expression profile along with system modeling has been
increasingly applied for personalized therapy. Now personalized chemotherapy, one of
personalized therapy, has been brought forward to the field of cancer. According to
protocol of personalized chemotherapy from tumor tissue sampling to clinical
application in queue, I will introduce the entire process including clinical sampling,
analyzing mRNA genomic expression level with its diagnosis, discovering gene
expression signature by system modeling and uncovering sensitive drugs from drugbank
for clinical application. At present, after next-generation sequencing is brought
into the new field, system modeling related with drugs discovery will make great
contribution for future personalized chemotherapy of tumor diseases.
Keywords: Cancer stem cells (CSCs), Circulating tumor cells (CTCs), Clinical
genomics analysis, Clinical genomic diagnosis, Drug targeting, Encyclopedia of
DNA Elements (ENCODE), Flow-cytometric cell sorting (FACS), Gene
expression signature (GES), Genome-wide association studies (GWAS), Lasercaptured
micro-dissection (LCM), Magnetic cell separation (MACS), Networks,
Personalized chemotherapy, Personalized medicine, Proteomics, Single nucleotide
polymorphisms (SNP), System biology and system modeling, Transcriptome.
