Frontiers in Protein and Peptide Sciences

Volume: 1

Heat Shock Response Agents and the Diseases

Author(s): Lütfi Tutar, Aykut Özgür, Esen Tutar, Kübra Açıkalın Coşkun and Yusuf Tutar

Pp: 139-160 (22)

DOI: 10.2174/9781608058624114010009

* (Excluding Mailing and Handling)


Heat shock proteins (Hsps) are highly conserved proteins and have cytoprotective role for maintaining cellular protein conformation. Hsps not only keep proteins in their native state but also involve in several essential biochemical process. This review summarizes structural properties of Hsps (Hsp70, Hsp40, Hsp90, Hsp100, Hsp60, sHsps, and Nucleotide Exchange Factors) and explains their roles in aging, apoptosis, cancer, neurodegeneration, cardio-vascular diseases, obesity and diabetes mellitus, and housekeeping.

Keywords: Apoptosis, cancer, Heat shock proteins, neurodegeneration, protein aggregation, protein folding.

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