The advent of bioinformatics and integrated biology approaches has given
rise to new avenues of diagnostic and therapeutic regimes. Living systems have been
explored to identify disease-associated biomarkers that facilitate the early diagnosis of
perilous medical conditions. Likewise, gene networks are pondered upon to obtain
better insights into biochemical systems that can assist in the prediction and testing of
the effects of various interactions within the systems. Genomics and proteomics-based
approaches are being explored to facilitate the early diagnosis of cancers, shifting the
paradigm towards noninvasive diagnostic alternatives. Bioinformatics has also fueled
pharmacogenomics and pharmacogenetics-based strategies that have in turn
contributed to the development of personalized medications. Similarly, the reverse
vaccinology approach has emerged as a prominent option to combat deadly pathogens
that were otherwise unrestrainable. This chapter highlights the fruits of integrated
bioinformatics in diagnosing and treating detrimental conditions.
Keywords: Integrated bioinformatics, Precision medicine, Computational diagnostic tools, In silico Therapeutics, Reverse vaccinology.