Multidrug-resistance (MDR) bacteria have emerged as a public health threat
in the modern era. Extended spectrum β-lactamase has emerged as the most successful
resistance mechanism among the Enterobacteriaceae family. ESBLs are often
mediated by blaTEM and blaCTX-M genes. The study evaluated the molecular
characteristics of ESBL-producing P. mirabilis isolates from the Klang River in order
to find the therapeutic options for ESBL infections. There appears to be a high
prevalence of CTX-M and TEM genes among P. mirabilis strains in the Klang River.
Therefore, rapid identification should be conducted for proper infection control and
antibiotic usage. Molecular techniques serve as a useful tool in the understanding of
MDR bacteria resistance.
Keywords: BlaTEM/blaCTX-M, ESBL, K. pneumoniae, MDR.
