Proteins are among the significant biomolecular constituents in a biosystem.
The structure of proteins and the nanomaterials, intracellular interactions, type of the
cell, cell organelles, cell signaling and sensation, etc., affect the interactions between
proteins and the nanomaterials. The interface formed between proteins and
nanomaterials is the original site of contact and the interplay. The behavior of the
interacting components reflects on the regulatory aspects, assembly of biomolecules,
and various applications in the normal functioning of a biosystem. The fundamentals
related to the tendency of biomolecules and nanomaterials help to retain their stable
physicochemical conformations. The interactions involving proteins and nanomaterials
bring changes in both. It is essential and beneficial to understand the mechanism of
these interactions and their impacts on each other. This chapter deals with the nature,
structure, and behavior of protein in general and nanomaterials, their stability, the
significance of zeta potential, opsonins and their role, protein corona, and the factors
influencing their dynamics.
Keywords: Biodistribution, Bionanointerface, Nanomaterials, Opsonization,
Protein Structure, Protein Corona, Protein Chip, Zeta Potential.
