Saffron, as one of the most expensive spices in the world, is obtained from
the stigma of Crocus sativus. Crocus sativus L. belongs to the Iridaceae family, and has
been widely used as an herbal medicine, spice, food coloring, and a flavoring agent
since ancient times. Saffron is one of the most famous plants cultivated in Iran, and this
country now accounts for approximately 90% of the world production of saffron.
Saffron has a long history in Islamic Traditional Medicine (ITM). It has been used for
the treatment of several diseases such as urogenital, ocular, and respiratory disorders.
Moreover, it has oxytocic, anti-depressant, aphrodisiac, cardioprotective, anticarcinogenic,
and anti-inflammatory properties. There are several studies on
pharmacological activities of saffron in vitro, in vivo, and clinical trials which not only
confirm the application of saffron in traditional medicine, but also introduce some new
medicinal aspects. In this chapter, we aim to present a comprehensive review on
traditional and ethnomedicinal uses of saffron in different systems of traditional
medicine, especially ITM. Then, we will discuss pharmacological activities reported
for saffron in modern medicine as in vitro, in vivo, and clinical trial studies. Finally, we
will compare the properties reported for saffron in traditional medicine with the
activities in modern medicine to reveal the potential of this valuable herb for treatment
of various diseases.
Keywords: Crocus sativus, Iridaceae, Islamic Traditional Medicine, Saffron.
