Title:Risk Factors for Different Grades of Lower Respiratory Tract Infections in Children Under Five Years Old with Measles: Based on Chest Radiography
Volume: 16
Author(s): Huanguo Li, Minming Zhang*, Qun Lao, Yushuang Ding, Kaiyu Zhao and Ruju Xu
Affiliation:
- Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou,China
Keywords:
Measles, child, lower respiratory tract infections, chest radiography, epidemic, pathogens.
Abstract:
Background: Although measles epidemic has been controlled effectively after measles
vaccination being carried out, China is still the focus of measles epidemic. The lower respiratory
tract infections (LRTIs) is the most common complication, and also the most common reason for
the death of patients with measles.
Purpose: To analyze what clinical factors could affect the grades of LRTIs in children under five
years old with measles.
Methods: Patients’ 13 clinical factors and chest radiography were analyzed retrospectively. Based
on the chest radiography, the LRTIs were divided into 3 grades. The clinical factors and the grades
of LRTIs were analyzed by ordered logistic regression analysis.
Results: There were 74 cases in grade 0, 77 cases in grade 1, and 36 cases in grade 2. After univariate
logistic regression analysis, there were 5 clinical factors whose P value were no more than
0.1, including the children’s course of disease before admission, co-infection other pathogens, vaccination,
the first symptoms and gender. After ordinal logistic regression analysis, the difference in
the course of disease before admission (OR = 1.134, 95% CI: 1.025 to 1.141), without vaccination
(OR = 1.808, 95% CI: 1.065 to 3.065) and co-infected other pathogens other pathogens infections
(OR = 1.618, 95% CI: 1.073 to 2.440) during different grades was statistically significant
(P < 0.05).
Conclusion: In our study, there were three clinical factors, including “with a long course of disease
before admission”, “without measles vaccination” and “with other pathogens infections”, as the independent
risk factors of the grades of LRTIs in children with measles.
