Title:Studies on Chloride Channels and their Modulators
Volume: 16
Issue: 16
Author(s): Vaishali M. Patil and Satya P. Gupta
Affiliation:
Keywords:
Chloride ion channels, Chloride channel modulators, Cystic fibrosis transmembrane conductance regulator,
Ligand-gated chloride channels.
Abstract: The prime roles of mutations in the genes, encoding chloride ion channels, in various human
diseases of muscle, kidney, bone and brain, such as congenital myotonia, myotonic dystrophy,
cystic fibrosis, osteopetrosis, epilepsy, glioma, etc., have been well established. Chloride ion channels
are also responsible for glioma progression in brain and malaria parasite in red blood cells. The present
article thus emphasises on the various diseases associated with chloride channel regulation and
their modulators. Studies on various chloride channels and their modulators have been discussed in
detail.
