Title:Metal Oxide Nanomaterials in Nanomedicine: Applications in Photodynamic Therapy and Potential Toxicity
Volume: 15
Issue: 18
Author(s): Xiaojia He, Winfred G. Aker, Ming-Ju Huang, John D. Watts and Huey-Min Hwang
Affiliation:
Keywords:
Cancer, Infectious pathogen, Metal oxide nanomaterials, Nanomedicine, Nanotoxicology, Photodynamic therapy,
Quantitative structural-activity relationship.
Abstract: Metal oxide nanomaterials have exhibited excellent performance as nanomedicines in photodynamic
therapy (PDT) for cancer and infection treatment. Their unique and tunable physicochemical
properties advance them as promising alternatives in drug delivery, early diagnosis, imaging, and
treatment against various tumors and infectious diseases. Moreover, the implementation of nanophototherapy
in deep tissue sites is enhanced by advancements in photosensitization technology. Notwithstanding
the progress made in emerging metal oxide nanomaterials-derived PDT, the potential toxicity
towards adjunct tissues associated with this approach remains challenging. Regulation and legislation have also been recommended
and subsequently enacted in response to public concerns related to large-scale production, transportation, use,
and disposal of those nanomaterials. Consequently, a quantitative structure-activity relationship (QSAR) paradigm has
been adopted and is widely used in evaluating and predicting the side effects of nanomedicines, thus influencing their design
and fabrication. This article briefly reviews the application of metal oxide nanomaterials in PDT and their associated
adverse impacts as reported in recent publications. The future trends and implications of this platform in nanomedicine are
also highlighted. However, more studies and efforts have to be carried out for developing novel nano-therapeutics with
high selectivity, sensitivity, biocompatibility, and minimal side effects in PDT.
