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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

Author(s): Simon E. Ward and Jeannette M. Watson

Volume 10, Issue 5, 2010

Page: [479 - 492] Pages: 14

DOI: 10.2174/156802610791111533

Price: $65


This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.

Keywords: 5-HT1D agonist, 5-HT1D antagonist, serotonin receptor, 5-HT receptor

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