Generic placeholder image

Recent Patents on Biotechnology


ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Systematic Review Article

Herbal Technological Prospects of Morus nigra L.: A Systematic Patent Analysis Review

Author(s): Larissa Pereira Alves*, Widson Michael dos Santos, Myla Lôbo de Souza, Larissa Araújo Rolim and Pedro José Rolim-Neto

Volume 18, Issue 3, 2024

Published on: 16 October, 2023

Page: [241 - 256] Pages: 16

DOI: 10.2174/1872208317666230821102411

Price: $65


Background: Morus nigra L. is a plant with significant potential for drug development due to the presence of numerous bioactive compounds in its various parts.

Objectives: This article aims to compile the technological perspectives of Morus nigra L. towards drug development and therapeutic indications based on registered patents in databases.

Methods: The study analyzed patents published within the last five years, focusing on products derived from different parts of the Morus nigra L. plant. Patent databases such as the European Patent Office (EPO), the United States Patent and Trademark Office (USPTO), the World Intellectual Property Organization (WIPO), and the National Institute of Industrial Property Databases (INPI) were examined.

Results: A total of 45 patents were categorized by country of origin, type of applicant, extraction method, and therapeutic indications. China had the highest number of patent filings (43.48%), and private companies were the primary technology patent holders (38.64%). Noteworthy extraction methods included ultrasound-assisted extraction, decoction, infusion, and maceration. The most utilized plant parts were leaves (44.44%), followed by fruits (35.56%), root bark (15.56%), and stems (4.44%). The main therapeutic indications identified were the treatment of hyperglycemia and dyslipidemia (43.33%), along with digestive problems, cosmetics, nutrition, and cleaning applications.

Conclusion: The study of patents covers discoveries and advancements often absent in scientific articles, making a review focused on this advanced information crucial for expanding existing scientific knowledge. Even if some therapies have been explored previously, patents can reveal innovative approaches and fresh perspectives that contribute to sustained scientific progress.

Keywords: Morus nigra L., patent analysis, biological activities, technological evolution, drug development, hyperglycemia.

Graphical Abstract
Koyu H, Kazan A, Demir S, Haznedaroglu MZ, Yesil-Celiktas O. Optimization of microwave assisted extraction of Morus nigra L. fruits maximizing tyrosinase inhibitory activity with isolation of bioactive constituents. Food Chem 2018; 248: 183-91.
[] [PMID: 29329842]
Temviriyanukul P, Sritalahareuthai V, Jom KN, et al. Comparison of phytochemicals, antioxidant, and in vitro anti-alzheimer properties of twenty-seven morus spp. cultivated in Thailand. Molecules 2020; 25(11): 2600.
[] [PMID: 32503261]
Nastić N, Borrás-Linares I, Lozano-Sánchez J, Švarc-Gajić J, Segura-Carretero A. Optimization of the extraction of phytochemicals from black mulberry (Morus nigra L.) leaves. J Ind Eng Chem 2018; 68: 282-92.
Araujo CM, Lúcio KP, Silva ME, et al. Morus nigra leaf extract improves glycemic response and redox profile in the liver of diabetic rats. Food Funct 2015; 6(11): 3490-9.
[] [PMID: 26294257]
Tang P, Yang X, Chen H, Zhang T, Tang H, Pang K. Anti-diabetic activity of extract from Morus nigra L. twigs through activation of AMPK/PKC pathway in mice. J Funct Foods 2022; 99: 105358.
Turan I, Demir S, Kilinc K, et al. Antiproliferative and apoptotic effect of Morus nigra extract on human prostate cancer cells. Saudi Pharm J 2017; 25(2): 241-8.
[] [PMID: 28344475]
Erden Y. Sour black mulberry (Morus nigra L.) causes cell death by decreasing mutant p53 expression in HT-29 human colon cancer cells. Food Biosci 2021; 42: 101113.
Akhlaq A, Mehmood MH, Rehman A, et al. The prokinetic, laxative, and antidiarrheal effects of Morus nigra: Possible muscarinic, Ca2+ channel blocking, and antimuscarinic mechanisms. Phytother Res 2016; 30(8): 1362-76.
[] [PMID: 27230535]
Padilha MM, Vilela FC, Rocha CQ, et al. Antiinflammatory properties of Morus nigra leaves. Phytother Res 2010; 24(10): 1496-500.
[] [PMID: 20878700]
Tchabo W, Ma Y, Engmann FN, Zhang H. Ultrasound-assisted enzymatic extraction (UAEE) of phytochemical compounds from mulberry (Morus nigra) must and optimization study using response surface methodology. Ind Crops Prod 2015; 63: 214-25.
Berg S, Wustmans M, Bröring S. Identifying first signals of emerging dominance in a technological innovation system: A novel approach based on patents. Technol Forecast Soc Change 2019; 146: 706-22.
Linares IMP, De Paulo AF, Porto GS. Patent-based network analysis to understand technological innovation pathways and trends. Technol Soc 2019; 59: 101134.
Schafranski K, Postigo M, Vitali L, Micke G, Richter W, Chaves E. Avaliação de compostos bioativos e atividade anti-oxidante de extratos de folhas de amoreira preta (Morus nigra L.) utilizando planejamento experimental. Quim Nova 2019; 42: 736-44.
Vukmirović S, Ilić V, Tadić V, et al. Comprehensive analysis of antioxidant and hepatoprotective properties of Morus nigra L. Antioxidants 2023; 12(2): 382.
[] [PMID: 36829941]
Chukwuma CI, Matsabisa MG, Ibrahim MA, Erukainure OL, Chabalala MH, Islam MS. Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review. J Ethnopharmacol 2019; 235: 329-60.
[] [PMID: 30769039]
Volpato GT, Calderon IMP, Sinzato S, Campos KE, Rudge MVC, Damasceno DC. Effect of Morus nigra aqueous extract treatment on the maternal–fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats. J Ethnopharmacol 2011; 138(3): 691-6.
[] [PMID: 21986227]
Pedrete TA, Hauser-Davis RA, Moreira JC. Proteomic characterization of medicinal plants used in the treatment of diabetes. Int J Biol Macromol 2019; 140: 294-302.
[] [PMID: 31422188]
Elena CA, Nela SM, Cristian TD, Ionel B, Daniel BI, Raluca PO. Nutritive supplement with hypoglycemic and antioxidant properties and process for preparing the same. RO128709A2, 2013.
Fogel S. Herbal compositions for the treatment of diabetes and/or conditions associated therewith. US0190446A1, 2015.
Peifang Z, Bicheli P, Balewall O. Composition containing morus berry. CN102204671A, 2011.
Leko V. Herbal composition and medicament against diabetes mellitus type II manufactured thereof. CN1243559C, 2006.
Leko V. Capsulated herbal composition as auxilary medicament against diabetes mellitus type (i) and (ii). WO034973A1, 2005.
Toru A. Mulberry leaf extract/ocimum containing composition. WO030234A1, 2005.
Hebin W, Aijun Q, Ling Y. Preparation method of oral insulin preparation using folium mori polysaccharide as carrier. CN109289040A, 2019.
Leko V. Herbal composition and type 2 diabetes mellitus drug manufactured therefrom. PI9917211-9A, 2002.
Zhang W, Ballevre O, Zhang P. Morus berries and avoiding glucose peaks. CN103998051A, 2014.
Leko V. Process and product extracted from herbal composition useful in controlling diabetes mellitus type II. US0206976A1, 2003.
Aijun H, Xiao H, Jun J, Wang Heyao, Yang W, Wu Jinwei. Use of flavonoid compound in preparation of metabolic disease resistance medicines. CN103393637A, 2013.
Hou A, Wang H, Wu J, Hu X, Wang Y, Jun J. Application of flavonoids compound in preparation of antimetabolic disease medicine. CN102579422A, 2012.
Shigenobu M. Calorie reducing agent. US2001018090A1, 2001.
Shigenobu M, Shinzo N. Intestinal controlling and constipation improving medicine and food and drink, and animal feed containing the same. JPH11335285A, 1999.
Yuexia Q. Traditional Chinese medicinal decoction for treating senile habitual constipation. CN105031461A, 2015.
Paolo BF. Compositions based on active principles of plant origin having eye protection action. WO2018134738A1, 2018.
Alice A. Antimicrobial phytotherapeutic product and process for preparing the same. RO122182B1, 2004.
Hiroyuki KT, Masahiko K. Antiviral composition. JP2004083527A, 2004.
Qingping T. Traditional Chinese medicinal capsules for treating autumn diarrhea in children. CN105031459A, 2015.
Shigenobu M, Shinzo N. Medicine for preventing drunken sickness and hangover. JP2002193823A, 2002.
Yuexia Q. Traditional Chinese medicinal capsules for treating infantile pneumonia. CN105030951A, 2015.
Qi D. Traditional Chinese medicine decoction for treating chronic bronchitis. CN104983831A, 2015.
Qi D. Traditional Chinese medicine decoction for treating chronic superficial gastritis. CN104984215A, 2015.
Qi D. Traditional Chinese medicine capsule for treating chronic superficial gastritis. CN104984214, 2015.
Zhiqiiu Y. Chinese medicinal decoction for treatment of ankylosing spondylitis. CN106237290, 2016.
Katrin K, Franca M. Detoxifying phytotherapeutic composition from two plant extracts and process for preparing the same. EP1338303A1, 2003.
Zeni ALB, Dalmagro AP. Process for obtaining compost from Morus nigral leaves. and compound obtained for the preparation of pharmaceutical formulations, nutraceuticals and food additives. BR102016029764-8A2, 2018.
de Castro AS, Borges ACR. Oral use formulations of the crude extract and fraction of the leaves of Morus nigra L. with anti-inflammatory properties. BR102016007882-2, 2015.
de Castro AS, Borges ACR. Formulation of pharmaceutical composition of lyophilized hydroalcoholic extract and/or active fractions of crushed or ground leaves of Morus nigra and its use in relieving menopausal symptoms. PI1105827-7A2, 2013.
Wufuer P. Uygur medicine composition wall-broken preparation for treating oral disease and production method. CN107137458A, 2017.
Hair care composition with cleaning and dandruff removing effects. CN108309895, 2018.
Du Yangbiao Y. Amino acid facial cleanser. CN110742819A, 2020.
Yiqun G, Dengping H, Jingmei W, Lei Z. Mild multi-effect repairing face cleanser and preparation method. 2018.
Ying L, Suoyuan X, Yun X. Bioremediation mask and preparation method thereof. CN108743448A, 2018.
Perrier E. Compositions and methods for inhibiting the formation of unwanted skin pigmentation US5773014A, 1998.
Masahiro KCT. Cosmetic or skin external preparation. JP2018172292A, 2018.
Huang Y. Tea cake hair-care composition and preparation method thereof. CN106692021A, 2017.
Hair blacking and nourishing cosmetic composition with seven black components and method for preparing hair blacking and nourishing cosmetic composition. CN106821856A, 2017.
Kerri G. Cosmetic methods and compositions for repairing human skin. WO2009023416A2, 2009.
Clyde G, Sian M. Cosmetic composition comprising botanical extracts and a thickener. EP1839641A1, 2007.
Mingbin X. Traditional Chinese medicine prescription for treating premature graying of hair. CN109481534A, 2019.
Léonor D. Root extracts from plants of the morus genus and uses of same. WO2019068824A1, 2019.
Jean-Jacques P. Cosmetic composition derived from morus method for extracting an active principle and resulting active principle. WO03043597A1, 2003.
Jacques PJ. Production of an agent with a soothing effect on stinging, burning and itching sensations and redness of the skin comprises extracting powdered mulberry leaves with water. FR2830754, 2003.
Xie C, Zou Y. Plant extract, compositions containing same, method of extraction and uses thereof. US8980343B2, 2015.
Harhaun R, Kunik O, Saribekova D, Lazzara G. Biologically active properties of plant extracts in cosmetic emulsions. Microchem J 2020; 154: 104543.
Rachmin I, Ostrowski SM, Weng QY, Fisher DE. Topical treatment strategies to manipulate human skin pigmentation. Adv Drug Deliv Rev 2020; 153: 65-71.
[] [PMID: 32092380]
Zorzi M, Gai F, Medana C, Aigotti R, Peiretti PG. Identification of polyphenolic compounds in edible wild fruits grown in the north-west of Italy by means of HPLC-DAD-ESI HRMS. Plant Foods Hum Nutr 2020; 75(3): 420-6.
[] [PMID: 32506297]
Maqsood M, Sharif MK. Phytochemical characterization of Morus nigra fruit ultrasound‐assisted. J Food Biochem 2022; 46(11): e14335.
Wang L, Wang J, Ma M, et al. Prenylated flavonoids from Morus nigra and their insulin sensitizing activity. Phytochemistry 2022; 203: 113398.
[] [PMID: 36041499]
Memete AR, Timar AV, Vuscan AN, Miere F, Venter AC, Vicas SI. Phytochemical composition of different botanical parts of morus species, health benefits and application in food industry. Plants 2022; 11(2): 152.
Tang C, Bao T, Zhang Q, et al. Clinical potential and mechanistic insights of mulberry (Morus alba L.) leaves in managing type 2 diabetes mellitus: Focusing on gut microbiota, inflammation, and metabolism. J Ethnopharmacol 2023; 306: 116143.
[] [PMID: 36632855]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy