This e-book presents an overview of the different substances capable of modulating potassium channels in relation to various clinical indications in cardiology, pulmonology, endocrinology and neurology. The possible benefits and side effects of potassium channel modulators is discussed in correlation with biophysical and pharmacological properties of ion channels. Readers will learn how mutation of K+ channels can be conferred by molecular processes such as alternative splicing, RNA editing and posttranslational modifications. Altogether, this e-book will be of use to clinical practitioners, electrophysiologists and pharmacologists interested in the complicated but fascinating science of potassium channels.