Inflammation triggers specific metabolic pathways and if not resolved, translates into several painful diseases such as rheumatoid arthritis, lupus, Alzheimer's disease, cardiovascular disorders and psoriasis. Various processes have been explored to understand the factors behind inflammation and consequently, many mechanisms have been examined to suppress it. The nucleotide-binding domain like receptor 3 (NLRP3) inflammasome is an example of such factors which is responsible for triggering sterile and microbe induced inflammation. Studies of genetic variants of the related gene have revealed insights into the mRNA expression pathways that may help researchers to identify crucial disease mechanisms. This book is a review of the scientific findings of distinguished scholars who have studied NLRP3 inflammasome activation and its contribution in worsening the outcomes of inflammatory disorders. This collection of chapters covers many aspects of the multifaceted role of NLRP3 inflammasome. Beginning with airway inflammation and fibrosis, it progresses to explore its involvement in pulmonary hypertension, heart diseases, tuberculosis, cardiovascular complications, and childhood asthma. Additionally, it examines the inflammasome's impact on protozoan parasitic infections and neuropathic pain. The chapters not only elucidate the intricate mechanisms of NLRP3 activation but also discuss potential inhibitors and therapeutic targets. Readers will gain a comprehensive understanding of the NLRP3 inflammasome's diverse implications across different physiological contexts. The book includes references making this book a valuable treatise of insights for researchers, clinicians, and healthcare professionals.

Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics is an essential reference for practicing dermatologists in hospitals and clinics. The book aims to provide interesting tips that cannot be found in traditional dermatology handbooks. The contributors include top minds in dermatology and related fields such as Joe Niamtu, Samuel Lam, and Steven Feldman. Topics in the book include novel, original formulations for topical compounds, ways to improve patient adherence to prescriptions, business tips, novelties in skin surgery, and solutions for preventing patient complaints and legal suits. The book also highlights the author's personal experiences gained over many years in improving everyday clinical dermatology practice. The book is divided into 5 sections each representing 'pearls' of advice: Teaching Pearls, Medical Pearls, Publication Pearls, Procedural Pearls, and Business Pearls, encompassing all of the broad realm of dermatology.

Geriatric Anesthesia: A Practical Guide is a comprehensive reference on geriatric anesthesia. The book is divided into three sections. The first section covers the basics of both anatomical and physiological changes in senescence, and important polypharmacy considerations common in elderly patients. The next section covers anesthesia for cardiac and non-surgical patients. Various controversies and legal ethical issues that are particularly significant in the elderly such as advance directives, code status discussions, specific patient groups and shared decision-making prior to surgical interventions, are covered in the final section. Key features - 20 referenced chapters covering basic geriatric anesthesia considerations, cardiac and non-surgical patients and special topics, respectively - Contributions and references from experienced anesthesiologists - Emphasis on tailoring perioperative management depending on specific circumstances of patients - Addresses novel and commonly overlooked topics related to the geriatric population This book is a guide for both anesthesia providers and non-anesthesia medical providers, trainees and students. It equips them with necessary information to understand and devise anesthetic plans while being aware of postoperative complications and the respective treatment and management options.