Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells. This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Individuals with Angelman Syndrome (AS) present many unique challenges to professionals, parents and others who are committed to maximizing individuals’ competence while ensuring them the best possible quality of life. Angelman Syndrome: Communication, Educational, and Related Considerations is a unique, exhaustive compilation of existing material related to understanding the nature of AS and how individuals’ communication and related skills can be fostered most effectively. It provides readers with a comprehensive understanding of the background of Angelman Syndrome along with an in-depth exploration of communication (with a focus on augmentative and alternative communication), educational, and related issues that should be addressed when attempting to meet the needs of individuals with AS at home, school, work, and elsewhere in the community. Key features of the book include: • Extensive background information about medical and related factors behind AS and how they influence individuals’ learning • A series of prologues written by the parents of individuals with AS • Contributions from internationally recognized experts on AS, communication disorders, psychology and education • Numerous practical, evidence-based strategies for conducting assessments and carrying out interventions among AS affected individuals Speech-language pathologists, allied healthcare providers and educators providing support to affected individuals should benefit from the information provided in the book by being able to identify appropriate communication, behavioral and educational goals. Laypersons, particularly parents, will also find the information highly useful in advocating for best practices for their children (which is partly fostered by the series of parental prologues). Angelman Syndrome: Communication, Educational, and Related Considerations will not only serve as a valuable reference for improving the learning experience for AS affected individuals but will also embolden both professionals and parents to maintain higher expectations for them.

This handbook focuses on the use of antibiotic alternatives in poultry and fish feed. Chapters in the book cover a range of natural ingredients in feed and the impacts of these natural feed additives on growth, production, reproduction and health status of poultry and fish. All chapters give a holistic approach to how organic feed additives (herbal plants and their extracts, probiotics, peptides, etc.) can positively impact animal health and production. Key Features: - presents 13 chapters contributed by 38 experts and scientists of animal, poultry and fish nutrition, poultry and fish physiology, toxicology, pharmacology, and pathology - highlights the significance of herbal plants and their extracts and derivatives, cold-pressed and essential oils and fruits by-products - covers the effects of special ingredients such as immunomodulators, antimicrobial peptides, and probiotics - provides the reader an updated perspective on the use of additives in poultry and fish industry as growth promoters and their role in developing bacterial resistance to antibiotics - covers the main poultry species, egg-laying hens, quails, geese, ducks, turkey, and commercial fish - includes references for advanced readers This book will be useful for poultry and fish keepers and researchers in animal nutrition, pharmacology, and veterinary sciences. Professionals involved in the poultry and fish feed industry will also find the information useful for product development.

Bentham Briefs in Biomedicine and Pharmacotherapy brings new trends and techniques in pharmacology and medical biochemistry to the forefront through unique volumes. Each volume provides a brief review of selected topics, written by scientific experts. The book series is essential reading for graduate students and researchers in pharmacology and life sciences as well as medical professionals seeking knowledge for research oriented projects. The first volume, Oxidative Stress and Natural Antioxidants, is a compilation of articles about free radicals (which are extremely reactive, short-lived molecules with unpaired electron valency), and antioxidants (which are stabilizing agents of free radicals in the body). The volume presents 17 chapters on the biochemistry of free radicals and antioxidants, with contributions from over 60 scientists. Readers will understand the basic and clinical aspects of free radical biomedicine, the role of antioxidants in neutralizing free radicals through physiological homeostasis, as well as the range of natural compounds which can be used to combat oxidative stress. The chapters also cover special topics such as recent advances in preparation methods of antioxidants, and industrial applications of antioxidants. The range of topics in this volume provide a consolidated reference for a broad set of readers on the subject.

Better Life and Business: Cell, Brain, Mind and Sex Universal Laws is an e-book that defines the fascinating new discipline: BRAINLIFEBIZ . BRAINLIFEBIZ combines new discoveries in neurobiology, behavior and medicine with novel concepts related to conscious software programming, automation, system adaptation, module selection , self -organization and automatic discovery. In other words, BRAINLIFEBIZ is a science of the consciousness, bio quantum / random chaos computations, self-organized event trains and processes with several conditions (continuous and discrete; without leadership and central control etc.). The goal of BRAINLIFEBIZ is to create a perfect computer model that simulates animal and human behavior in a computerized experimental setting. This volume presents simulations of the firefly, cricket, katydid, frog, bird and human prefrontal cortex. The book breaks across the lines that separate scientific disciplines. It explains the global nature of the specific intelligent systems outlined above. These intelligent systems features include learning, self- organization, fuzzy logic, high speed signal processing and process control. These features are employed to generate an intelligence map. The map presents figures and equations, curves and data for major ‘Elementary Processes’: aggression, mimicry, chaos , trains, pile up, attractions, courting, mating, emotion, reasoning and consciousness . ‘Elementary Processes’ are then simulated to interact with each other and form millions of complex processes explained by universal laws behind the cell, brain, mind, sex. These laws explain, in a new way, natural selection and reproductive success in the local and global society and business. These laws can be applied in a variety of situations - from everyday stress-free life, to intelligent business decision making, but with a solid biomedical and scientific foundation. The theory behind intelligent systems can be viewed as a complement to the genetic DNA code. The brain generates various brain event trains which allow it to store information in dispersed neural networks (biologically speaking, in 25 billions of neurons some of which with thousands of synapses dispersed over the cortex). The book explains the fast, precise and clear neural diagnostic processas well as the extremely flexible powerful leader mind. Better Life and Business: Cell, Brain, Mind and Sex Universal Laws is, therefore, a valuable reference for researchers to the fascinating world of natural and man -made intelligent systems and their applications in business situations and personal lives.

Aluminium is a chemical element present in earth’s crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease. Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book. Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.

Biochemistry: Fundamentals and Bioenergetics presents information about the basic and applied aspects of the chemistry of living organisms. The textbook covers the scope and importance of biochemistry, the latest physical techniques to determine biomolecular structure, detailed classification, structure and function of biomolecules such as carbohydrates, lipids, amino acids, proteins, nucleic acids, vitamins, enzymes and hormones. Readers will also learn about processes central to energy metabolism including photosynthesis and respiration, oxidative phosphorylation, DNA replication, transcription and translation, recombinant DNA technology. Key Features - logical approach to biochemistry with several examples - 10 organized chapters on biochemistry fundamentals and metabolism - focus on biomolecules and biochemical processes - references for further reading

This brief book is dedicated to the quantitative analyses and systematic discussion of spatial biodiversity and biogeographic patterns in the Asia‐pacific region comprised of China, India and adjacent countries. The book is split into two sections. The first section presents readers with detailed statistical methods to conduct spatial macro‐biodiversity and biogeography analyses. Step-by-step instructions on how to perform these statistical methods by using the statistical program R are also provided. In the second part, different quantitative case studies are presented covering several topics, including phylogenetics, spatial statistics, multivariate statistics and ecological genomics. Each case study concludes with a detailed interpretation of the quantitative results and how these results are relevant to local and regional ecological processes. This reference is suitable for academics interested in biostatistics biodiversity and ecological studies specific to the Asia Pacific region and China.

Most findings about molecular interactions and cellular regulatory events are published in peer-reviewed scientific literature in the form of scientific jargon. The computerized text-mining algorithms are used to convert free grammar of human language into a set of formalized relationships between biological concepts in order to use this wealth of information. The compendium of such interactions extracted from an entire set of biomedical literature is a called knowledge network. Knowledge networks are the first step in the process of digitizing molecular biological knowledge. The next step is building molecular models depicting principal molecular events that govern various biological processes. Data mining in knowledge networks is the essence of building new biological models. The purpose is to elucidate major pathways of information flow through a molecular physical interaction network that happens during a disease, a cell process or an experiment. Such models contain key proteins involved in the process and can be used for prioritizing disease targets, for understanding of drug action and prevention of drug-induced toxicities, for analysis of patient predispositions and design of personalized therapies, for design of diagnostic biomarkers and analysis of patient molecular data. This e-book contains detailed examples illustrating the path to the digital biology and computerized drug development for personalized medicine. It provides conceptual principals for building biological models and for applying the models to make predictions relevant for drug development and translational medicine. The e-book will also be useful for researchers who use high-throughput technologies for molecular profiling of disease and drug action. It provides examples for analysis of gene expression microarrays to infer biological models, to find biomarkers for drug response and for applications of high-throughput molecular profiling technologies for personalized medicine. Scientists in academia, in pharmaceutical industry as well as graduate students will benefit from reading this book. The illustrations from the book can also be readily used in taught courses for molecular biology and pharmacology.