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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Recent Advances in the Use of Algal Polysaccharides for Skin Wound Healing

Author(s): Suneel Kumar, Ileana Marrero-Berrios, Maciej Kabat and Francois Berthiaume*

Volume 25, Issue 11, 2019

Page: [1236 - 1248] Pages: 13

DOI: 10.2174/1381612825666190521120051

Price: $65


Background: Chronic skin wounds and pressure ulcers represent major health care problems in diabetic individuals, as well as patients who suffered a spinal cord injury. Current treatment methods are only partially effective and such wounds exhibit a high recurrence rate. Open wounds are at high risk of invasive wound infections, which can lead to amputation and further disability. An interdisciplinary approach is needed to develop new and more effective therapies.

Methods: The purpose of this work is to review recent studies focusing on the use of algal polysaccharides in commercially available as well as experimental wound dressings. Studies that discuss wound dressings based on algal polysaccharides, some of which also contain growth factors and even living cells, were identified and included in this review.

Results and Conclusion: Algal polysaccharides possess mechanical and physical properties, along with excellent biocompatibility and biodegradability that make them suitable for a variety of applications as wound dressings. Furthermore, algal polysaccharides have been used for a dual purpose, namely as wound covering, but also as a vehicle for drug delivery to the wound site.

Keywords: Skin, spinal cord injury, diabetic ulcer, pressure ulcer, wound dressing, drug delivery, algal polysaccharides.

Boateng J, Catanzano O. Advanced Therapeutic Dressings for Effective Wound Healing-A Review. J Pharm Sci 2015; 104(11): 3653-80.
[] [PMID: 26308473]
Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med 2017; 376(24): 2367-75.
[] [PMID: 28614678]
Rappl LM. Physiological changes in tissues denervated by spinal cord injury tissues and possible effects on wound healing. Int Wound J 2008; 5(3): 435-44.
[] [PMID: 18205787]
Marin J, Nixon J, Gorecki C. A systematic review of risk factors for the development and recurrence of pressure ulcers in people with spinal cord injuries. Spinal Cord 2013; 51(7): 522-7.
[] [PMID: 23588570]
Kumar S, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Impact of complete spinal cord injury on healing of skin ulcers in mouse models. J Neurotrauma 2018; 35(6): 815-24.
[] [PMID: 29160147]
Sen CK. Human Wounds and Its Burden: An Updated Compendium of Estimates. Adv Wound Care (New Rochelle) 2019; 8(2): 39-48.
[] [PMID: 30809421]
Singh S, Young A, McNaught C-E. The physiology of wound healing. Surgery. Oxford International Edition 2017; 35: pp. 473-7. []
Skórkowska-Telichowska K, Czemplik M, Kulma A, Szopa J. The local treatment and available dressings designed for chronic wounds. J Am Acad Dermatol 2013; 68(4): e117-26.
[] [PMID: 21982060]
Bhatnagar M, Bhatnagar A. Wound dressings from algal polymers 2015. 523-556. DOI: 10.1002/9783527679577.ch31.
Lee KY, Mooney DJ. Alginate: properties and biomedical applications. Prog Polym Sci 2012; 37(1): 106-26.
[] [PMID: 22125349]
Aderibigbe BA, Buyana B. Alginate in Wound Dressings. Pharmaceutics 2018; 10(2): 42.
[] [PMID: 29614804]
de Jesus Raposo MF, de Morais AMB, de Morais RMSC. Marine polysaccharides from algae with potential biomedical applications. Mar Drugs 2015; 13(5): 2967-3028.
[] [PMID: 25988519]
Błaszak BB, Gozdecka G, Shyichuk A. Carrageenan as a functional additive in the production of cheese and cheese-like products. Acta Sci Pol Technol Aliment 2018; 17(2): 107-16.
[PMID: 29803212]
Ahmed A, Taha R. Marine Phytochemical Compounds and Their Cosmeceutical Applications 2011; pp. 51-62. []
Berger M, Welle A, Gottwald E, Rapp M, Länge K. Biosensors coated with sulfated polysaccharides for the detection of hepatocyte growth factor/scatter factor in cell culture medium. Biosens Bioelectron 2010; 26(4): 1706-9.
[] [PMID: 20719493]
Demajo JK, Cassar V, Farrugia C, et al. Effectiveness of disinfectants on antimicrobial and physical properties of dental impression materials. Int J Prosthodont 2016; 29(1): 63-7.
[] [PMID: 26757331]
Rahim SA, Carter PA, Elkordy AA. Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug. Drug Des Devel Ther 2015; 9: 1843-57.
[PMID: 25848220]
Kumar S, Babiarz J, Basak S, et al. Sizes and Sufficient Quantities of MSC Microspheres for Intrathecal Injection to Modulate Inflammation in Spinal Cord Injury. Nano Life 2015; 5(4): 5.
[] [PMID: 29545904]
Venkatesan J, Bhatnagar I, Manivasagan P, Kang KH, Kim SK. Alginate composites for bone tissue engineering: a review. Int J Biol Macromol 2015; 72: 269-81.
[] [PMID: 25020082]
Popa EG, Caridade SG, Mano JF, Reis RL, Gomes ME. Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications. J Tissue Eng Regen Med 2015; 9(5): 550-63.
[] [PMID: 23303734]
Ramu Ganesan A, Shanmugam M, Bhat R. Producing novel edible films from semi refined carrageenan (SRC) and ulvan polysaccharides for potential food applications. Int J Biol Macromol 2018; 112: 1164-70.
[] [PMID: 29454950]
Chandrasekaran S, Iyer M. Toothpaste comprising calcium-based abrasives United States Patents US20140127143A1.
Allison G, O’leary N. Carrageenan gel air freshener United States European Patent Office EP2750721A1, 2014.
Choi JI, Kim HJ. Preparation of low molecular weight fucoidan by gamma-irradiation and its anticancer activity. Carbohydr Polym 2013; 97(2): 358-62.
[] [PMID: 23911457]
Kim Y-I, Oh W-S, Song PH, et al. Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice. Mar Drugs 2018; 16(8): 286.
[] [PMID: 30126169]
Qi H, Zhang Q, Zhao T, Hu R, Zhang K, Li Z. In vitro antioxidant activity of acetylated and benzoylated derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta). Bioorg Med Chem Lett 2006; 16(9): 2441-5.
[] [PMID: 16481163]
Chiellini F, Morelli A. Ulvan: A Versatile Platform of Biomaterials from Renewable Resources. INTECH Open Access Publisher 2011.
Leiro JM, Castro R, Arranz JA, Lamas J. Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh. Int Immunopharmacol 2007; 7(7): 879-88.
[] [PMID: 17499190]
Qi H, Huang L, Liu X, Liu D, Zhang Q, Liu S. Antihyperlipidemic activity of high sulfate content derivative of polysaccharide extracted from Ulva pertusa (Chlorophyta). Carbohydr Polym 2012; 87: 1637-40.
Lynch MB, Sweeney T, Callan JJ, O’Sullivan JT, O’Doherty JV. The effect of dietary Laminaria-derived laminarin and fucoidan on nutrient digestibility, nitrogen utilisation, intestinal microflora and volatile fatty acid concentration in pigs. J Sci Food Agric 2010; 90(3): 430-7.
[PMID: 20355064]
Jaswir I, Hammed A. Anti-inflammatory compounds of macro algae origin: A review. J Med Plants Res 2011; 5(33): 7146-54.
Chang Y, Peng Y, Li P, Zhuang Y. Practices and exploration on competition of molecular biological detection technology among students in food quality and safety major. Biochem Mol Biol Educ 2017; 45(4): 343-50.
[] [PMID: 28696055]
Shalumon KT, Anulekha KH, Nair SV, Nair SV, Chennazhi KP, Jayakumar R. Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings. Int J Biol Macromol 2011; 49(3): 247-54.
[] [PMID: 21635916]
Qin Y. The characterization of alginate wound dressings with different fiber and textile structures. J Appl Polym Sci 2006; 100: 2516-20.
Lee W-R, Park J-H, Kim K-H, et al. The biological effects of topical alginate treatment in an animal model of skin wound healing. Wound Repair Regen 2009; 17: 505-10.
Wang T, Gu Q, Zhao J, et al. Calcium alginate enhances wound healing by up-regulating the ratio of collagen types I/III in diabetic rats. Int J Clin Exp Pathol 2015; 8(6): 6636-45.
[PMID: 26261545]
Kim JO, Park JK, Kim JH, et al. Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. Int J Pharm 2008; 359(1-2): 79-86.
[] [PMID: 18440737]
Murakami K, Aoki H, Nakamura S, et al. Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings. Biomaterials 2010; 31(1): 83-90.
[] [PMID: 19775748]
Saarai A, Kasparkova V, Sedlacek T, Saha P. A comparative study of crosslinked sodium alginate/gelatin hydrogels for wound dressing. Proceedings of the 4th WSEAS international conference on Energy and development - environment - biomedicine. World Scientific and Engineering Academy and Society (WSEAS). 2011; pp. In: Corfu Island, Greece; 384-9.
Pereira R, Carvalho A, Vaz DC, Gil MH, Mendes A, Bártolo P. Development of novel alginate based hydrogel films for wound healing applications. Int J Biol Macromol 2013; 52: 221-30.
[] [PMID: 23059189]
Saarai A, Sedlacek T, Kasparkova V, Kitano T, Saha P. On the characterization of sodium alginate/gelatine-based hydrogels for wound dressing. J Appl Polym Sci 2012; 126: E79-88.
Xing N, Tian F, Yang J, Li YK. Characterizations of Alginate-Chitosan Hydrogel for Wound Dressing Application Adv Mater Res 2012; 490-495: 3124-3128.
Pandima Devi M, Sekar M, Chamundeswari M, et al. A novel wound dressing material — fibrin–chitosan–sodium alginate composite sheet. Bull Mater Sci 2012; 35: 1157-63.
Pereira R, Carvalho A, Vaz DC, Gil MH, Mendes A, Bártolo P. Development of novel alginate based hydrogel films for wound healing applications. Int J Biol Macromol 2013; 52: 221-30.
[] [PMID: 23059189]
Zhou Z, Chen J, Peng C, et al. Fabrication and Physical Properties of Gelatin/Sodium Alginate/Hyaluronic Acid Composite Wound Dressing Hydrogel. J Macromol Sci Part A 2014; 51: 318-25.
Rudyardjo D, Wijayanto S. The synthesis and characterization of hydrogel chitosan-alginate with the addition of plasticizer lauric acid for wound dressing application 2017. []
Park SA, Park KE, Kim W. Preparation of sodium alginate/poly(ethylene oxide) blend nanofibers with lecithin. Macromol Res 2010; 18: 891-6.
Coşkun G, Karaca E, Ozyurtlu M, Ozbek S, Yermezler A, Cavuşoğlu I. Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo. Biomed Mater Eng 2014; 24(2): 1527-36.
[PMID: 24642979]
Hu C, Gong RH, Zhou FL. Electrospun Sodium Alginate/Polyethylene Oxide Fibers and Nanocoated Yarns. Int J Polym Sci 2015; 2015: 12.
Rivadeneira J, Audisio MC, Gorustovich A. Films based on soy protein-agar blends for wound dressing: Effect of different biopolymer proportions on the drug release rate and the physical and antibacterial properties of the films. J Biomater Appl 2018; 32(9): 1231-8.
[] [PMID: 29409375]
Bao L, Yang W, Mao X, Mou S, Tang S. Agar/collagen membrane as skin dressing for wounds. Biomed Mater 2008; 3(4)044108
[] [PMID: 19029613]
Miguel SP, Ribeiro MP, Brancal H, Coutinho P, Correia IJ. Thermoresponsive chitosan-agarose hydrogel for skin regeneration. Carbohydr Polym 2014; 111: 366-73.
[] [PMID: 25037363]
Mohd Zohdi R, Abu Bakar Zakaria Z, Yusof N, Mohamed Mustapha N, Abdullah MNH. Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing. Evid Based Complement Alternat Med 2012; 2012843025
[] [PMID: 21941590]
Sen M, Avci EN. Radiation synthesis of poly(N-vinyl-2-pyrrolidone)-kappa-carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests. J Biomed Mater Res A 2005; 74(2): 187-96.
[] [PMID: 15962270]
Awanthi D, De Silva DA. Development of a PVP/kappa-carrageenan/PEG hydrogel dressing for wound healing applications in Sri Lanka. J Natl Sci Found Sri Lanka 2011; 39(1): 25-33.
Mihaila SM, Gaharwar AK, Reis RL, Marques AP, Gomes ME, Khademhosseini A. Photocrosslinkable kappa-carrageenan hydrogels for tissue engineering applications. Adv Healthc Mater 2013; 2(6): 895-907.
[] [PMID: 23281344]
Garcia-Vaquero M, Rajauria G, O’Doherty JV, Sweeney T. Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification. Food Res Int 2017; 99(Pt 3): 1011-20.
[] [PMID: 28865611]
O’Leary R, Rerek M, Wood EJ. Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair. Biol Pharm Bull 2004; 27(2): 266-70.
[] [PMID: 14758050]
Sezer AD, Hatipoğlu F, Cevher E, Oğurtan Z, Baş AL, Akbuğa J. Chitosan film containing fucoidan as a wound dressing for dermal burn healing: preparation and in vitro/in vivo evaluation. AAPS PharmSciTech 2007; 8(2): 39.
[] [PMID: 17622117]
Sezer AD, Cevher E, Hatipoğlu F, Oğurtan Z, Baş AL, Akbuğa J. Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits. Biol Pharm Bull 2008; 31(12): 2326-33.
[] [PMID: 19043221]
Webber JL, Benbow NL, Krasowska M, Beattie DA. Formation and enzymatic degradation of poly-l-arginine/fucoidan multilayer films. Colloids Surf B Biointerfaces 2017; 159: 468-76.
[] [PMID: 28837896]
Toskas G, Hund R-D, Laourine E, Cherif C, Smyrniotopoulos V, Roussis V. Nanofibers based on polysaccharides from the green seaweed Ulva Rigida. Carbohydr Polym 2011; 84(3): 1093-102.
Alves A, Sousa RA, Reis RL. Processing of degradable ulvan 3D porous structures for biomedical applications. J Biomed Mater Res A 2013; 101(4): 998-1006.
[] [PMID: 22965453]
Kikionis S, Ioannou E, Toskas G, Roussis V. Electrospun biocomposite nanofibers of ulvan/PCL and ulvan/PEO. J Appl Polym Sci 2015; 132: 42153.
Gainza G, Villullas S, Pedraz JL, Hernandez RM, Igartua M. Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration. Nanomedicine (Lond) 2015; 11(6): 1551-73.
[] [PMID: 25804415]
Thu H-E, Zulfakar MH, Ng S-F. Alginate based bilayer hydrocolloid films as potential slow-release modern wound dressing. Int J Pharm 2012; 434(1-2): 375-83.
[] [PMID: 22643226]
Singh R, Singh D. Radiation synthesis of PVP/alginate hydrogel containing nanosilver as wound dressing. J Mater Sci Mater Med 2012; 23(11): 2649-58.
[] [PMID: 22886579]
Liakos I, Rizzello L, Scurr DJ, Pompa PP, Bayer IS, Athanassiou A. All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties. Int J Pharm 2014; 463(2): 137-45.
[] [PMID: 24211443]
Nazeri S, Mirabzadeh Ardakani E, Babavalian H, Latifi AM. Evaluation of Effectiveness of Honey-Based Alginate Hyrogel on Wound Healing in a Mouse Model of Rat. J Appl Biotechnol Rep 2015; 2(3): 293-7.
Kamoun EA, Kenawy E-RS, Tamer TM, El-Meligy MA, Mohy Eldin MS. Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation. Arab J Chem 2015; 8: 38-47.
Mohandas A, Kumar PTS, Raja B, Lakshmanan V-K, Jayakumar R. Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds. Int J Nanomedicine 2015; 10(Suppl. 1): 53-66.
[PMID: 26491307]
Straccia MC, d’Ayala GG, Romano I, Oliva A, Laurienzo P. Alginate hydrogels coated with chitosan for wound dressing. Mar Drugs 2015; 13(5): 2890-908.
[] [PMID: 25969981]
Yu W, Jiang Y-Y, Sun T-W, et al. Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing. RSC Advances 2016; 6: 104375-87.
Coskun GUKE, Ozbek S, Cavugoslu I. In vivo evaluation of electrospun poly (vinyl alcohol)/sodium alginate nanofibrous mat as wound dressing. Tekstil Ve Konfeksiyon 2010; 20: 290-8.
Hajiali H, Summa M, Russo D, et al. Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing. J Mater Chem B Mater Biol Med 2016; 4: 1686-95.
Fu R, Li C, Yu C, et al. A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application. Drug Deliv 2016; 23(3): 828-39.
[] [PMID: 24870202]
Hegge AB, Andersen T, Melvik JE, Bruzell E, Kristensen S, Tønnesen HH. Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: studies on curcumin and curcuminoides XLII. J Pharm Sci 2011; 100(1): 174-85.
[] [PMID: 20575064]
Valerón Bergh VJ, Johannessen E, Andersen T, Tønnesen HH. Evaluation of porphyrin loaded dry alginate foams containing poloxamer 407 and β-cyclodextrin-derivatives intended for wound treatment. Pharm Dev Technol 2018; 23(8): 761-70.
[] [PMID: 28359224]
Boateng J, Burgos-Amador R, Okeke O, Pawar H. Composite alginate and gelatin based bio-polymeric wafers containing silver sulfadiazine for wound healing. Int J Biol Macromol 2015; 79: 63-71.
[] [PMID: 25936500]
Matthews KH, Stevens HNE, Auffret AD, Humphrey MJ, Eccleston GM. Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. Int J Pharm 2005; 289(1-2): 51-62.
[] [PMID: 15652198]
Pawar HV, Boateng JS, Ayensu I, Tetteh J. Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. J Pharm Sci 2014; 103(6): 1720-33.
[] [PMID: 24700434]
Gowda D. Design and development of antimicrobial wafers for chronic wound healing 2016. 8(7): 70-79.
Daniel-da-Silva AL, Moreira J, Neto R, Estrada A, Gil A, Trindade T. Impact of magnetic nanofillers in the swelling and release properties of κ-carrageenan hydrogel nanocomposites. Carbohydr Polym 2012; 87(1): 328-35.
Boateng JS, Pawar HV, Tetteh J. Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing. Int J Pharm 2013; 441(1-2): 181-91.
[] [PMID: 23228898]
Padhi JR, Nayak D, Nanda A, Rauta PR, Ashe S, Nayak B. Development of highly biocompatible Gelatin & i-Carrageenan based composite hydrogels: In depth physiochemical analysis for biomedical applications. Carbohydr Polym 2016; 153: 292-301.
[] [PMID: 27561499]
Nair AV, Raman M, Doble M. Cyclic β-(1→3) (1→6) glucan/carrageenan hydrogels for wound healing applications. RSC Advances 2016; 6: 98545-53.
Zeng HY, Huang YC. Basic fibroblast growth factor released from fucoidan-modified chitosan/alginate scaffolds for promoting fibroblasts migration. J Polym Res 2018; 25: 83.
Morelli A, Chiellini F. Ulvan as a New Type of Biomaterial from Renewable Resources: Functionalization and Hydrogel Preparation. Macromol Chem Phys 2010; 211: 821-32.
Alves A, Pinho ED, Neves NM, Sousa RA, Reis RL. Processing ulvan into 2D structures: cross-linked ulvan membranes as new biomaterials for drug delivery applications. Int J Pharm 2012; 426(1-2): 76-81.
[] [PMID: 22281048]
Morelli A, Betti M, Puppi D, Bartoli C, Gazzarri M, Chiellini F. Enzymatically Crosslinked Ulvan Hydrogels as Injectable Systems for Cell Delivery. Macromol Chem Phys 2016; 217: 581-90.

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