Abstract
Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the current therapy of cancer despite their side effects. The general area of research relates to heterocyclic chemistry. The purpose of the article is to review the most recent advances in nitrogen-containing heterocyclics as possible chemotherapy agents for cancer. More than 90% of the novel drugs bear heterocyclics and among them, nitrogencontaining heterocyclic compounds show superior pharmaceutical effect than non-nitrogen compounds. Nitrogen-containing compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in the metabolism of living cells.
Keywords: Anticancer, heterocyclic, nitrogen-containing heterocyclic, natural nitrogen-containing heterocyclic, synthetic nitrogencontaining heterocyclic, chemotherapy agents.
Current Organic Chemistry
Title:Anti-cancer Nitrogen-Containing Heterocyclic Compounds
Volume: 22 Issue: 23
Author(s): Zahra Hosseinzadeh, Ali Ramazani*Nima Razzaghi-Asl
Affiliation:
- Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan,Iran
Keywords: Anticancer, heterocyclic, nitrogen-containing heterocyclic, natural nitrogen-containing heterocyclic, synthetic nitrogencontaining heterocyclic, chemotherapy agents.
Abstract: Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the current therapy of cancer despite their side effects. The general area of research relates to heterocyclic chemistry. The purpose of the article is to review the most recent advances in nitrogen-containing heterocyclics as possible chemotherapy agents for cancer. More than 90% of the novel drugs bear heterocyclics and among them, nitrogencontaining heterocyclic compounds show superior pharmaceutical effect than non-nitrogen compounds. Nitrogen-containing compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in the metabolism of living cells.
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Cite this article as:
Hosseinzadeh Zahra, Ramazani Ali*, Razzaghi-Asl Nima, Anti-cancer Nitrogen-Containing Heterocyclic Compounds, Current Organic Chemistry 2018; 22 (23) . https://dx.doi.org/10.2174/1385272822666181008142138
DOI https://dx.doi.org/10.2174/1385272822666181008142138 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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