Abstract
The progressive supranuclear palsy is a progressive neurodegenerative disease characterized by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration in PSP is associated with tau protein, but the mechanisms by which tau abnormalities lead to cell dysfunction and death are not well understood.
Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical implications. Careful planning involving patients’ families, academic and industry researchers were necessary to ensure improvement in quality of life.
Keywords: Progressive supranuclear palsy, tonopathy, movement disorders, bioethics, clinical ethics, cognitive disease.
Current Alzheimer Research
Title:Progressive Supranuclear Palsy: Neuropsychopathological, Therapeutical and Bioethical Aspects
Volume: 15 Issue: 10
Author(s): Ignazio Vecchio, Cristina Tornali, Giulia Malaguarnera, Nicola Luigi Bragazzi and Michele Malaguarnera*
Affiliation:
- Research Center ,Italy
Keywords: Progressive supranuclear palsy, tonopathy, movement disorders, bioethics, clinical ethics, cognitive disease.
Abstract: The progressive supranuclear palsy is a progressive neurodegenerative disease characterized by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration in PSP is associated with tau protein, but the mechanisms by which tau abnormalities lead to cell dysfunction and death are not well understood.
Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical implications. Careful planning involving patients’ families, academic and industry researchers were necessary to ensure improvement in quality of life.
Export Options
About this article
Cite this article as:
Vecchio Ignazio , Tornali Cristina , Malaguarnera Giulia , Bragazzi Luigi Nicola and Malaguarnera Michele *, Progressive Supranuclear Palsy: Neuropsychopathological, Therapeutical and Bioethical Aspects, Current Alzheimer Research 2018; 15 (10) . https://dx.doi.org/10.2174/1567205015666180507111958
DOI https://dx.doi.org/10.2174/1567205015666180507111958 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Alzheimer's Disease Drug Development
Alzheimer's disease is a progressive neurodegenerative disorder that affects millions of people worldwide. Despite decades of research, no cure or disease-modifying treatment is available yet. Therefore, the need for developing effective therapies to treat Alzheimer's disease is an urgent matter. This special issue aims to provide a comprehensive overview of ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clear Shot at Primary Aim: Susceptibility of Trypanosoma cruzi Organelles, Structures and Molecular Targets to Drug Treatment
Current Topics in Medicinal Chemistry Fc Receptor Signaling in Leukocytes: Role in Host Defense and Immune Regulation
Current Immunology Reviews (Discontinued) Paliperidone: A Clinical Review
Current Drug Therapy Protein-mediated Fatty Acid Uptake in the Heart
Current Cardiology Reviews Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions
Current Pharmaceutical Design Perinatal Depression, Fetal Bonding, and Mother-Child Attachment: A Review of the Literature
Current Pediatric Reviews Glutamate Receptors in Human Caudate Nucleus in Normal Aging and Alzheimer’s Disease
Current Alzheimer Research Computational Development of Selective nNOS Inhibitors: Binding Modes and Pharmacokinetic Considerations
Current Medicinal Chemistry The Therapeutic Potential of Adenosine Triphosphate as an Immune Modulator in the Treatment of HIV/AIDS: A Combination Approach with HAART
Current HIV Research Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Obstructive Sleep Apnea and Hypertension: A Bidirectional Causal Relation
Current Respiratory Medicine Reviews Extracellular Citrate in Health and Disease
Current Molecular Medicine Selective Serotonin Reuptake Inhibitors in Pregnancy
Current Medicinal Chemistry Metabolomics by Imaging; Biochemical-Magnetic Resonance Correlation: What We Learn from Combined Data of Magnetic Resonance Spectroscopy, NMR Spectroscopy, Clinical Chemistry and Tissue Content Analysis? Major Bottlenecks in Diagnosis
Recent Patents on Medical Imaging Behavioral Effects of 2,3-Dihydro- and Oxoisoaporphine Derivatives in Post Stroke-Depressive Like Behavior in Male Balb/c Mice
Current Topics in Medicinal Chemistry Avascular Necrosis of Humeral Trochlea: A Case Report of the Rare Condition
Current Medical Imaging Effectiveness and Safety Profile of <i>Ginkgo biloba</i> Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment
CNS & Neurological Disorders - Drug Targets T-Type Calcium Channels and Thalamocortical Rhythms in Sleep: A Perspective from Studies of T-Type Calcium Channel Knockout Mice
CNS & Neurological Disorders - Drug Targets Interventional Radiology in Paediatrics
Current Pediatric Reviews Structure-controlled Nanomaterial Synthesis using Surfactant-assisted Ball Milling- A Review
Current Nanoscience