Title:Fe-S Proteins Acting as Redox Switch: New Key Actors of Cellular Adaptive Responses
Volume: 11
Issue: 2
Author(s): Marie-Pierre Golinelli-Cohen*Cécile Bouton*
Affiliation:
- Institut de Chimie des Substances Naturelles, UPR 2301-CNRS, 1 avenue de la Terrasse 91190 Gif-sur-Yvette, Cedex,France
- Institut de Chimie des Substances Naturelles, UPR 2301-CNRS, 1 avenue de la Terrasse 91190 Gif-sur-Yvette, Cedex,France
Keywords:
Fe-S cluster, sensor, redox state, cellular adaptive response, mitoNEET, iron.
Abstract: Abstract: Background: Iron-sulfur clusters are inorganic prosthetic groups composed of only iron and
inorganic sulfur atoms. Organisms develop different pathways to sense their local environment and to
respond and adapt to changes.
Objective: We focused on Fe-S-containing proteins, which control their activity in response to redox
signals by changing the redox state of their cluster.
Result: When reduced, these Fe-S cluster-containing sensors are all inactive. As soon as their cluster
perceives a signal that induces its oxidation, they switch to an « active state ».
Conclusion: This sensing mechanism efficiently helps cells to turn on survival pathways quickly and
recover from stressful conditions.
