摘要
背景:多形性成胶质细胞瘤(GBM)持续侵害患者,尽管临床医师对其生物学、发病机制和治疗进展进行了研究,研究人员仍难以控制该类肿瘤。相比于原肿瘤,GBM具有明显的基因差异性,它不可避免地以一种更加侵略性和耐药性的方式复发,常规性地比较多原则治疗方案活的更久。为了进一步不断获得更多信息将GBM点朝类干细胞表型的方向发展。这些癌肿肝细胞与目前大多数恶性肿瘤类似,能够在许多易感肿瘤中发生。 结论:胶质瘤干细胞由其肿瘤的发展、修复和复发的预期研究因此也变成了当前研究热点。胶质瘤干细胞能够浸润肿瘤周围白质,常常难以被切除。特殊的是,他们在生化和环境方面能够抵抗当前可利用的最好的治疗,本能地及有效地抵制标准化疗和放疗。这些胶质瘤干细胞产生了一种异源性肿瘤以致到目前为止每一种治疗性的问题都有一个答案,患者的死亡率仍较低。针对胶质瘤干细胞的患者进行研究可能是在GBM中达到持久疗效的关键。
关键词: 化疗,药物靶向,多形性成胶质细胞瘤,胶质瘤干细胞,生态位,阻力,重现
Current Cancer Drug Targets
Title:Hitting a Moving Target: Glioma Stem Cells Demand New Approaches in Glioblastoma Therapy
Volume: 17 Issue: 3
关键词: 化疗,药物靶向,多形性成胶质细胞瘤,胶质瘤干细胞,生态位,阻力,重现
摘要: Background: Glioblastoma multiforme (GBM) continues to devastate patients and outfox investigators and clinicians despite the preponderance of research directed at its biology, pathogenesis and therapeutic advances. GBM routinely outlasts multidisciplinary treatment protocols, almost inevitably recurring in a yet more aggressive and resistant form with distinct genetic differences from the original tumor. Attempts to glean further insight into GBM point increasingly toward a subpopulation of cells with a stem-like phenotype. These cancer stem cells, similar to those now described in a variety of malignancies, are capable of tumorigenesis from a population of susceptible cells.
Conclusions: Glioma stem cells have thus become a prevalent focus in GBM research for their presumed role in development, maintenance and recurrence of tumors. Glioma stem cells infiltrate the white matter surrounding tumors and often evade resection. They are uniquely suited both biochemically and environmentally to resist the best therapy currently available, intrinsically and efficiently resistant to standard chemo- and radiotherapy. These stem cells create an extremely heterogenous tumor that to date has had an answer for every therapeutic question, with continued dismal patient survival. Targeting this population of glioma stem cells may hold the long-awaited key to durable therapeutic efficacy in GBM.Export Options
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Cite this article as:
Hitting a Moving Target: Glioma Stem Cells Demand New Approaches in Glioblastoma Therapy, Current Cancer Drug Targets 2017; 17 (3) . https://dx.doi.org/10.2174/1568009616666161215161924
DOI https://dx.doi.org/10.2174/1568009616666161215161924 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
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