Abstract
Interstitial lung disease (ILD) has been described as a potential clinical finding in essentially all of the connective tissue diseases (CTD). Patients with Rheumatoid Arthritis most commonly develop a fibrotic pattern consistent with Usual Interstitial Pneumonia while Non-Specific Interstitial Pneumonia is more commonly seen in the remainder of the collagen vascular diseases, in particular in patients with Scleroderma-spectrum disease. The etiology of ILD in the CTDs is poorly understood and the progression of lung disease may not correlate with the more typical autoimmune manifestations. Therapy of CTD-associated ILD remains unsatisfactory and the clinical picture may be clouded by the probability that some patients with apparently idiopathic ILD will, eventually, evolve into a more clearly-defined CTD and by the possibility that in some patients with lung-dominant disease subtle evidence of underlying CTD may be missed. In this review we will examine the etiologic, histologic, radiographic, and epidemiologic features of the Idiopathic Intersitial Pneumonias in comparison with their CTD-associated counterparts as well as address some of the difficulties in assessing whether ILD is truly idiopathic or instead part of an underlying autoimmune process.
Keywords: Idiopathic interstitial pneumonia, non-specific interstitial pneumonia, organizing pneumonia, rheumatoid arthritis, systemic sclerosis, usual interstitial pneumonia.
Current Respiratory Medicine Reviews
Title:Comparison of Idiopathic Interstitial Pneumonias with Their Connective Tissue Disease-Associated Counterparts
Volume: 11 Issue: 2
Author(s): Charles F. Moore and Rafael L. Perez
Affiliation:
Keywords: Idiopathic interstitial pneumonia, non-specific interstitial pneumonia, organizing pneumonia, rheumatoid arthritis, systemic sclerosis, usual interstitial pneumonia.
Abstract: Interstitial lung disease (ILD) has been described as a potential clinical finding in essentially all of the connective tissue diseases (CTD). Patients with Rheumatoid Arthritis most commonly develop a fibrotic pattern consistent with Usual Interstitial Pneumonia while Non-Specific Interstitial Pneumonia is more commonly seen in the remainder of the collagen vascular diseases, in particular in patients with Scleroderma-spectrum disease. The etiology of ILD in the CTDs is poorly understood and the progression of lung disease may not correlate with the more typical autoimmune manifestations. Therapy of CTD-associated ILD remains unsatisfactory and the clinical picture may be clouded by the probability that some patients with apparently idiopathic ILD will, eventually, evolve into a more clearly-defined CTD and by the possibility that in some patients with lung-dominant disease subtle evidence of underlying CTD may be missed. In this review we will examine the etiologic, histologic, radiographic, and epidemiologic features of the Idiopathic Intersitial Pneumonias in comparison with their CTD-associated counterparts as well as address some of the difficulties in assessing whether ILD is truly idiopathic or instead part of an underlying autoimmune process.
Export Options
About this article
Cite this article as:
F. Moore Charles and L. Perez Rafael, Comparison of Idiopathic Interstitial Pneumonias with Their Connective Tissue Disease-Associated Counterparts, Current Respiratory Medicine Reviews 2015; 11 (2) . https://dx.doi.org/10.2174/1573398X11666150619181948
DOI https://dx.doi.org/10.2174/1573398X11666150619181948 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Chronic obstructive pulmonary disease (COPD) from childhood to adulthood: from the past to the future
Chronic obstructive pulmonary disease (COPD) is one of the three leading causes of death worldwide, with a major prevalence in low- and middle-income countries, resulting in a high social and economic cost. It is a heterogeneous respiratory disease, treatable and preventable, that causes persistent and often progressive airway obstruction in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Functional Chemical Groups that May Likely Become a Source for the Synthesis of Novel Central Nervous System (CNS) Acting Drugs
Central Nervous System Agents in Medicinal Chemistry Pharmacological, Immunological, and Gene Targeting of the Renin-Angiotensin System for Treatment of Cardiovascular Disease
Current Pharmaceutical Design Neurovascular Mechanisms of Hypertension in Pregnancy
Current Neurovascular Research Drug Therapies in the Secondary Prevention of Cardiovascular Diseases:Successes, Shortcomings and Future Directions
Current Vascular Pharmacology Therapeutic Application of Histone Deacetylase Inhibitors for Stroke
Central Nervous System Agents in Medicinal Chemistry Preface: EDITORIAL COMMENT “Perfect 24-hr Blood Pressure Control” From Morning to Nocturnal Hypertension: Up-To-Date 2015
Current Hypertension Reviews Anti-diabetic Drug Metformin: Challenges and Perspectives for Cancer Therapy
Current Cancer Drug Targets Is the Vascular System a Main Target for Thyroid Hormones? From Molecular and Biochemical Findings to Clinical Perspectives
Current Vascular Pharmacology Role for Poly(ADP-ribose) Polymerase Activation in Diabetic Nephropathy, Neuropathy and Retinopathy
Current Vascular Pharmacology Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology
Current Pharmaceutical Design Perivascular Adipose Tissue as an Endocrine Organ: The Role of Statins
Current Pharmaceutical Design MicroRNAs: Novel Diagnostic and Prognostic Biomarkers in Atherosclerosis
Current Topics in Medicinal Chemistry The Extra-Hematopoietic Role of Erythropoietin in Diabetes Mellitus
Current Diabetes Reviews Mood Stabilizers, Oxidative Stress and Antioxidative Defense in Euthymia of Bipolar Disorder
CNS & Neurological Disorders - Drug Targets Association and Causal Relationship of Midlife Obesity and Related Metabolic Disorders with Old Age Cognition
Current Alzheimer Research NADPH Oxidases and Inflammatory Bowel Disease
Current Medicinal Chemistry The Impact of Folate Status on the Efficacy of Colorectal Cancer Treatment
Current Drug Metabolism Endothelial Dysfunction: Methods of Assessment & Implications for Cardiovascular Diseases
Current Pharmaceutical Design Thrombolytic Therapy in Peripheral Arterial Disease
Current Drug Targets - Cardiovascular & Hematological Disorders Erectile Dysfunction and Diabetes Mellitus: Mechanistic Considerations from Studies in Experimental Models
Current Diabetes Reviews