Title:Drug-Loaded Nanocarriers in Tumor Targeted Drug Delivery
Volume: 4
Issue: 3
Author(s): Meerza Abdul Razak, Shankarappa Devi Prasad Boggupalli and Buddolla Viswanath
Affiliation:
Keywords:
Active targeting, antibody based therapy, passive targeting, receptor, targeting tumors, tumor site.
Abstract: Background: Cancer cells are more susceptible than normal cells to the effect of chemotherapeutic
agents and most of the anticancer drugs can cause harm to the normal cells. Optimum dose and
frequency are both important factors in the persistence of cancer cells during cancer chemotherapy.
Now attempts have been focusing on efforts to kill cancer cells by more specific targeting while
sparing the normal cells by drug loaded nanocarriers.
Methods: We review technical papers and other articles related to nanoparticles, which have been
developed as effective target specific strategies for cancer treatment, acting as nanocarriers and also as
active agents.
Results: This review will allow to gain a more general view of the various drug loaded nanocarriers which offers a
predominantly unique set of chemical, physical and photonic properties for better drug delivery to the tumor tissues based
on morphological and functional differences between normal and tumor tissues.
Conclusion: Nanoparticulate delivery systems in cancer therapies provide better penetration of therapeutic and diagnostic
substances with the cancerous tissue in comparison to conventional cancer therapies. Thus nanocarriers can be used for
strategic development of novel drug delivery systems and reformulating existing drugs to enhance effectiveness.
