Title:Human Induced Pluripotent Stem Cells for Inherited Cardiovascular Diseases Modeling
Volume: 11
Issue: 7
Author(s): Wenjian Jiang, Feng Lan and Hongjia Zhang
Affiliation:
Keywords:
Congenital heart disease, induced pluripotent stem cells, inherited arrhythmia, inherited cardiomyopathy.
Abstract: Cardiovascular cells derived from patient specific induced Pluripotent Stem
Cell (iPSC) harbor gene mutations associated with the pathogenesis of inherited cardiac
diseases and congenital heart diseases (CHD). Numerous reports have demonstrated
the utilization of human induced Pluripotent Stem Cell (hiPSC) to model cardiac
diseases as a means of investigating their underlying mechanisms. So far, they
have been shown to investigate the molecular mechanisms of many cardiac disorders,
such as long-QT syndrome (LQT), catecholaminergic polymorphic ventricular tachycardia
(CPVT), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy
(HCM), LEOPARD syndrome (LS), arrhythmogenic cardiomyopathy (ACM), Friedreich
ataxia (FRDA), Barth syndrome (BTHS), hypoplastic left heart syndrome (HLHS), Marfan syndrome
(MFS) and other CHD. This article summarizes the growing body of research related to modeling
various cardiac diseases using hiPSCs. Moreover, by reviewing the methods used in previous studies, we
propose multiple novel applications of hiPSCs to investigate comprehensive cardiovascular disorders and
facilitate drug discovery.
