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Abstract
Spinal cord injury is a devastating, traumatic event, and experienced mainly among young people. Until the modern era, spinal cord injury was so rapidly fatal that no seriously injured persons would survive long enough for regeneration to occur. Treatment of spinal cord injury can be summarized as follows: prevent further cord injury, maintain blood flow, relieve spinal cord compression, and provide secure vertebral stabilization so as to allow mobilization and rehabilitation, none of which achieves functional recovery. Previous studies have focused on analyzing the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as the tissue damage and neural cell death associated with secondary injury. Now, there are hundreds of current experimental and clinical regenerative treatment studies. One of the most popular treatment method is cell transplantation in injured spinal cord. For this purpose bone marrow stromal cells, mononuclear stem cells, mesenchymal stem cells, embryonic stem cells, neural stem cells, and olfactory ensheathing cells can be used. As a result, cell transplantation has become a promising therapeutic option for spinal cord injury patients. In this paper we discuss the effectiveness of stem cell therapy in spinal cord injury.
Keywords: Cell transplantation, marrow stromal cells, mesenchymal stem cells, regeneration, spinal cord, stem cells, tissue engineering, Spinal cord injury, Embryonic stem cells.
Current Stem Cell Research & Therapy
Title:Regenerative Treatment in Spinal Cord Injury
Volume: 7 Issue: 5
Author(s): Mevci Ozdemir, Ayhan Attar and Isinsu Kuzu
Affiliation:
Keywords: Cell transplantation, marrow stromal cells, mesenchymal stem cells, regeneration, spinal cord, stem cells, tissue engineering, Spinal cord injury, Embryonic stem cells.
Abstract: Spinal cord injury is a devastating, traumatic event, and experienced mainly among young people. Until the modern era, spinal cord injury was so rapidly fatal that no seriously injured persons would survive long enough for regeneration to occur. Treatment of spinal cord injury can be summarized as follows: prevent further cord injury, maintain blood flow, relieve spinal cord compression, and provide secure vertebral stabilization so as to allow mobilization and rehabilitation, none of which achieves functional recovery. Previous studies have focused on analyzing the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as the tissue damage and neural cell death associated with secondary injury. Now, there are hundreds of current experimental and clinical regenerative treatment studies. One of the most popular treatment method is cell transplantation in injured spinal cord. For this purpose bone marrow stromal cells, mononuclear stem cells, mesenchymal stem cells, embryonic stem cells, neural stem cells, and olfactory ensheathing cells can be used. As a result, cell transplantation has become a promising therapeutic option for spinal cord injury patients. In this paper we discuss the effectiveness of stem cell therapy in spinal cord injury.
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Cite this article as:
Ozdemir Mevci, Attar Ayhan and Kuzu Isinsu, Regenerative Treatment in Spinal Cord Injury, Current Stem Cell Research & Therapy 2012; 7 (5) . https://dx.doi.org/10.2174/157488812802481481
DOI https://dx.doi.org/10.2174/157488812802481481 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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