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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Microglia Phenotype Diversity

Author(s): M. Olah, K. Biber, J. Vinet and H. W.G.M. Boddeke

Volume 10, Issue 1, 2011

Page: [108 - 118] Pages: 11

DOI: 10.2174/187152711794488575

Price: $65


Microglia, the tissue macrophages of the brain, have under healthy conditions a resting phenotype that is characterized by a ramified morphology. With their fine processes microglia are continuously scanning their environment. Upon any homeostatic disturbance microglia rapidly change their phenotype and contribute to processes including inflammation, tissue remodeling, and neurogenesis. In this review, we will address functional phenotypes of microglia in diverse brain regions and phenotypes associated with neuroinflammation, neurogenesis, brain tumor homeostasis, and aging.

Keywords: Microglia, aging, gliomas, white matter, grey matter, inflammation, MHC II, TREM2b, LCA, fibronectin, vitronectin, neurohypophysis, amyotrophic lateral, Alzheimer's disease, encephalomyelitis, EAE, prostaglandin, TGF-1, stroke, cyclooxygenase-2, CD86, HLA-DR, activation and complement, astrocytomas, metalloprotease, glioblastomas, Parkinson's disease

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