On the Involvement of H2S in Nitroso Signaling and Other Mechanisms of H2S Action

Zuzana      Tomaskova; Anna      Bertova; Karol      Ondrias

Abstract

Both endogenously produced and exogenously administered H2S exert numerous biological effects. However, the molecular mechanisms underlying these effects are not fully understood. This review surveys the biological effects of H2S and summarizes the molecular mechanisms of H2S action. It focuses on the role of H2S/HS--induced NO release from nitroso compounds, modulation of ion channels and the antioxidant and radical properties of H2S in the molecular mechanism of its effects. The potential involvement of H2S in nitroso signaling underlying its diverse biological effects is also discussed.

Keywords: Antioxidant, aorta, hydrogen sulfide, ion channel, nitric oxide, nitroso signaling, relaxation, sulfhydryl radical, exert numerous biological effects, nitroso compounds, hydrophobic, gasotransmitter, thoracic aorta, cystathionine -lyase (CSE), carbon monoxide (CO), nonvascular smooth muscle