Abstract
During the past few decades, the potential of treating infections with nitric oxide (NO) has been firmly demonstrated in various laboratories. Both in vitro and in vivo studies have afforded promising results in terms of reducing microbial loads in chronic wounds in addition to its utility in keeping medical devices free of thrombus formation and bacterial adhesion. The latter antimicrobial effects of NO provide great help in successful integration of orthopedic and vascular implants and prolonging their in vivo life. In all such applications, NO is released from various polymeric materials in which nitrite salts, exogenous NO donors, or even simple NO(g) are incorporated. Recent developments in all such formulations of NO-releasing materials and their specific applications in combating bacteria, fungi and parasites are reviewed in this article.
Keywords: Nitric oxide (NO), infection, wounds, antimicrobial, platelet adhesion, antithrombic, NO donors, polymers, NOreleasing material, metal nitrosyls.
Anti-Infective Agents in Medicinal Chemistry
Title: Emerging Antimicrobial Applications of Nitric Oxide (NO) and NO-Releasing Materials
Volume: 9 Issue: 4
Author(s): Genevieve M. Halpenny and Pradip K. Mascharak
Affiliation:
Keywords: Nitric oxide (NO), infection, wounds, antimicrobial, platelet adhesion, antithrombic, NO donors, polymers, NOreleasing material, metal nitrosyls.
Abstract: During the past few decades, the potential of treating infections with nitric oxide (NO) has been firmly demonstrated in various laboratories. Both in vitro and in vivo studies have afforded promising results in terms of reducing microbial loads in chronic wounds in addition to its utility in keeping medical devices free of thrombus formation and bacterial adhesion. The latter antimicrobial effects of NO provide great help in successful integration of orthopedic and vascular implants and prolonging their in vivo life. In all such applications, NO is released from various polymeric materials in which nitrite salts, exogenous NO donors, or even simple NO(g) are incorporated. Recent developments in all such formulations of NO-releasing materials and their specific applications in combating bacteria, fungi and parasites are reviewed in this article.
Export Options
About this article
Cite this article as:
M. Halpenny Genevieve and K. Mascharak Pradip, Emerging Antimicrobial Applications of Nitric Oxide (NO) and NO-Releasing Materials, Anti-Infective Agents in Medicinal Chemistry 2010; 9 (4) . https://dx.doi.org/10.2174/187152110794785086
DOI https://dx.doi.org/10.2174/187152110794785086 |
Print ISSN 1871-5214 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6018 |
Related Articles
-
Sudden Infant Death Syndrome: Implications of Altered Physiological Control During Sleep
Current Pediatric Reviews Autonomic Neural Functions in Space
Current Pharmaceutical Biotechnology Computational Studies of Competitive Inhibitors of Nitric Oxide Synthase (NOS) Enzymes: Towards the Development of Powerful and Isoform-Selective Inhibitors
Current Medicinal Chemistry Non-Analgesic Effects of Opioids: Cardiovascular Effects of Opioids and their Receptor Systems
Current Pharmaceutical Design Amniotic Fluid Embolism: Moving Diagnosis Through the Time. From the Mechanical Pulmonary Vascular Occlusion Until An Immuno - Inflammatory Pathogenesis?
Current Pharmaceutical Biotechnology Exploiting Novel Cell Cycle Targets in the Development of Anticancer Agents
Current Cancer Drug Targets Pharmacological and Biological Activities of Benzazepines: An Overview
Current Bioactive Compounds Treatment of the Cheyne-Stokes Breathing Pattern in Patients with Congestive Heart Failure: An Update
Current Respiratory Medicine Reviews Pharmacological Effects of RAAS Blockade in Ischemic Nephropathy
Current Drug Metabolism Nutritional Aspects Relating to the Developmental Origins of Health and Disease
Current Women`s Health Reviews New Indications for Corticosteroids in Intensive Care Units
Current Drug Targets Subject Index To Volume 4
Current Vascular Pharmacology α-Synuclein Misfolding and Neurodegenerative Diseases
Current Protein & Peptide Science Effects of Plant Extracts on HIV-1 Protease
Current HIV Research Nanowired Drug Delivery of Antioxidant Compound H-290/51 Enhances Neuroprotection in Hyperthermia-Induced Neurotoxicity
CNS & Neurological Disorders - Drug Targets Scorpion Toxin Polyptides as Therapeutic Agents: An Overview
Protein & Peptide Letters Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body
Mini-Reviews in Medicinal Chemistry Third Generation Radiopharmaceuticals for Imaging and Targeted Therapy
Current Pharmaceutical Analysis Vascular Endothelial Growth Factor (VEGF) Biochemistry and Development of Inhibitory Drugs
Current Drug Therapy Choice of Treatment with Antidepressants: Influencing Factors
Current Pharmaceutical Design