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Current Respiratory Medicine Reviews

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ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

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Research Article

Assessing Lung Function and Quality of Life in COVID-19 Patients: A Pilot Study

Author(s): Mitra Samareh Fekri, Faranak Salajegheh*, Mohammad Rezaei Zadeh Rukerd, Mohsen Nakhaie, Maliheh Sadat Bazrafshani, Fatemeh Goharriz and Mohammad Sadegh Shahmoradzadeh Miri

Volume 20, Issue 1, 2024

Published on: 01 January, 2024

Page: [58 - 64] Pages: 7

DOI: 10.2174/011573398X268451231212111328

Price: $65

Abstract

Background and Objective: Respiratory complications of COVID-19 should be considered as critical concerns that require prompt medical intervention. The aim of this study was to examine the impact of COVID-19 on pulmonary function and quality of life among recovered patients through a three-month follow-up period.

Methods: This pilot study aimed to assess the pulmonary functions and quality of life in 32 COVID-19 survivors at Afzalipour Hospital, Kerman, Iran. Pulmonary functions were evaluated using spirometry to evaluate FVC, FEV1, PEF, and FEV1/FVC. Quality of life was measured using the SF-36 questionnaire, which evaluated eight health-related concepts. Statistical analysis was performed using SPSS v23.

Results: Among the 32 survivors of COVID-19, 41.6% and 59.4% were male and female, respectively. The mean length of hospitalization for admitted patients (56.3% of all patients) was 10.89 days. Male survivors exhibited significantly lower values in FEV1 (3.06 vs. 4.05, p = 0.02), PEF (6.45 vs. 10.58, p = 0.002), and FEF-25-75 (3.17 vs. 4.94, p = 0.008) compared to healthy males of the same age. For female survivors, all pulmonary indices were significantly lower than healthy females of the same age. Regarding quality of life, there was no statistical significance between male and female survivors. However, when compared with healthy populations, survivors obtained lower scores in various quality-of-life items. Male survivors had notably lower scores in physical functioning (3.17 vs. 4.94, p = 0.008) and physical role (40.38 vs. 73.8, p = 0.008). Female survivors scored considerably lower than the healthy population in all quality of life items, except for role emotional and mental health.

Conclusion: COVID-19 survivors had lower pulmonary indices and quality of life compared to healthy individuals of the same sex and age, with female survivors exhibiting worse conditions.

Keywords: COVID 19, pulmonary function, spirometry, respiratory complications, mental health, lung function.

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[1]
WHO. WHO Coronavirus (COVID-19) Dashboard. 2021. Available from:https://covid19.who.int/
[2]
World Health Organization. WHO EMRO COVID-19 situation updates for week 22 (30 May - 5 June 2021). 2021. Available from:https://www.emro.who.int/pandemic-epidemic-diseases/covid-19/covid-19-situation-updates-for-week-22-30-may-5-june-2021.html
[3]
Sun P, Qie S, Liu Z, Ren J, Li K, Xi J. Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis. J Med Virol 2020; 92(6): 612-7.
[http://dx.doi.org/10.1002/jmv.25735] [PMID: 32108351]
[4]
Surveillances V. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19)-China, 2020. China CDC weekly 2020; 2(8): 113-22.
[5]
Carfì A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA 2020; 324(6): 603-5.
[http://dx.doi.org/10.1001/jama.2020.12603] [PMID: 32644129]
[6]
Ahmed H, Patel K, Greenwood D, et al. Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis. J Rehabil Med 2020; 52(5): 0.
[http://dx.doi.org/10.2340/16501977-2694] [PMID: 32449782]
[7]
Liang L, Yang B, Jiang N, et al. Three-month follow-up study of survivors of coronavirus disease 2019 after discharge. J Korean Med Sci 2020; 35(47): e418.
[http://dx.doi.org/10.3346/jkms.2020.35.e418] [PMID: 33289374]
[8]
Salem AM, Al Khathlan N, Alharbi AF, et al. The Long-term impact of covid-19 pneumonia on the pulmonary function of survivors. Int J Gen Med 2021; 14: 3271-80.
[http://dx.doi.org/10.2147/IJGM.S319436] [PMID: 34267545]
[9]
Sibley CG, Greaves LM, Satherley N, et al. Effects of the COVID-19 pandemic and nationwide lockdown on trust, attitudes toward government, and well-being. Am Psychol 2020; 75(5): 618-30.
[http://dx.doi.org/10.1037/amp0000662] [PMID: 32496074]
[10]
van der Sar - van der Brugge S, Talman S, Boonman - de Winter LJM, et al. Pulmonary function and health-related quality of life after COVID-19 pneumonia. Respir Med 2021; 176: 106272.
[http://dx.doi.org/10.1016/j.rmed.2020.106272] [PMID: 33302142]
[11]
Ma YF, Li W, Deng HB, et al. Prevalence of depression and its association with quality of life in clinically stable patients with COVID-19. J Affect Disord 2020; 275: 145-8.
[http://dx.doi.org/10.1016/j.jad.2020.06.033] [PMID: 32658818]
[12]
Chen KY, Li T, Gong FH, Zhang JS, Li XK. Predictors of health-related quality of life and influencing factors for COVID-19 patients, a follow-up at one month. Front Psychiatry 2020; 11: 668.
[http://dx.doi.org/10.3389/fpsyt.2020.00668] [PMID: 32733299]
[13]
Hui DS, Joynt GM, Wong KT, et al. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax 2005; 60(5): 401-9.
[http://dx.doi.org/10.1136/thx.2004.030205] [PMID: 15860716]
[14]
Golshan M, Nematbakhsh M, Amra B, Crapo RO. Spirometric reference values in a large Middle Eastern population. Eur Respir J 2003; 22(3): 529-34.
[http://dx.doi.org/10.1183/09031936.03.00003603] [PMID: 14516147]
[15]
Montazeri A, Goshtasebi A, Vahdaninia M, Gandek B. The Short Form Health Survey (SF-36): Translation and validation study of the Iranian version. Qual Life Res 2005; 14(3): 875-82.
[http://dx.doi.org/10.1007/s11136-004-1014-5] [PMID: 16022079]
[16]
Zhao Y, Shang Y, Song W, et al. Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine 2020; 25: 100463.
[http://dx.doi.org/10.1016/j.eclinm.2020.100463] [PMID: 32838236]
[17]
Lerum TV, Aaløkken TM, Brønstad E, et al. Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19. Eur Respir J 2021; 57(4): 2003448.
[http://dx.doi.org/10.1183/13993003.03448-2020] [PMID: 33303540]
[18]
Fumagalli A, Misuraca C, Bianchi A, et al. Pulmonary function in patients surviving to COVID-19 pneumonia. Infection 2021; 49(1): 153-7.
[http://dx.doi.org/10.1007/s15010-020-01474-9] [PMID: 32725597]
[19]
Finney LJ, Doughty R, Lovage S, Spurr L, Mehta B, Kemp SV, et al. Lung function deficits and symptom burden in survivors of COVID-19 requiring mechanical ventilation. Ann Am Thorac Soc 2021; 18(10): 1740-3.
[20]
Mo X, Jian W, Su Z, et al. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur Respir J 2020; 55(6): 2001217.
[http://dx.doi.org/10.1183/13993003.01217-2020] [PMID: 32381497]
[21]
Santus P, Flor N, Saad M, et al. Trends over time of lung function and radiological abnormalities in COVID-19 pneumonia: A prospective, observational, cohort study. J Clin Med 2021; 10(5): 1021.
[http://dx.doi.org/10.3390/jcm10051021] [PMID: 33801455]
[22]
Li X, Wang C, Kou S, Luo P, Zhao M, Yu K. Lung ventilation function characteristics of survivors from severe COVID-19: A prospective study. Crit Care 2020; 24(1): 300.
[http://dx.doi.org/10.1186/s13054-020-02992-6] [PMID: 32505211]
[23]
Albitar O, Ballouze R, Ooi JP, Sheikh Ghadzi SM. Risk factors for mortality among COVID-19 patients. Diabetes Res Clin Pract 2020; 166: 108293.
[http://dx.doi.org/10.1016/j.diabres.2020.108293] [PMID: 32623035]
[24]
Acheampong DO, Barffour IK, Boye A, Aninagyei E, Ocansey S, Morna MT. Male predisposition to severe COVID-19: Review of evidence and potential therapeutic prospects. Biomed Pharmacother 2020; 131: 110748.
[http://dx.doi.org/10.1016/j.biopha.2020.110748] [PMID: 33152916]
[25]
Connor J, Madhavan S, Mokashi M, et al. Health risks and outcomes that disproportionately affect women during the Covid-19 pandemic: A review. Soc Sci Med 2020; 266: 113364.
[http://dx.doi.org/10.1016/j.socscimed.2020.113364] [PMID: 32950924]
[26]
Venturelli S, Benatti SV, Casati M, et al. Surviving COVID-19 in Bergamo province: A post-acute outpatient re-evaluation. Epidemiol Infect 2021; 149: e32.
[http://dx.doi.org/10.1017/S0950268821000145] [PMID: 33461632]
[27]
Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et al. Attributes and predictors of Long-COVID: Analysis of COVID cases and their symptoms collected by the Covid Symptoms Study App. Medrxiv 2020; 2020
[http://dx.doi.org/10.1101/2020.10.19.20214494]
[28]
Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, et al. Physical, cognitive and mental health impacts of COVID-19 following hospitalisation-a multi-centre prospective cohort study. MedRxiv 2021; 2021
[29]
Méndez R, Latorre A, González-Jiménez P, Feced L, Bouzas L, Yépez K, et al. Reduced diffusion capacity in COVID-19 survivors. Ann Am Thorac Soc 2021; 8(7): 1253-5.
[30]
Bellan M, Soddu D, Balbo PE, Baricich A, Zeppegno P, Avanzi GC, et al. Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge. JAMA 2021; 4(1): e2036142.
[31]
Huang L, Yao Q, Gu X, et al. 1-year outcomes in hospital survivors with COVID-19: A longitudinal cohort study. Lancet 2021; 398(10302): 747-58.
[http://dx.doi.org/10.1016/S0140-6736(21)01755-4] [PMID: 34454673]
[32]
Lindahl A, Aro M, Reijula J, Mäkelä MJ, Ollgren J, Puolanne M, et al. Women report more symptoms and impaired quality of life: A survey of Finnish COVID-19 survivors. Infect Dis 2021; •••: 1-10.
[PMID: 34410220]
[33]
Sheehy LM. Considerations for postacute rehabilitation for survivors of COVID-19. JMIR Public Health Surveill 2020; 6(2): e19462.
[http://dx.doi.org/10.2196/19462] [PMID: 32369030]
[34]
Coffman KE, Carlson AR, Miller AD, Johnson BD, Taylor BJ. The effect of aging and cardiorespiratory fitness on the lung diffusing capacity response to exercise in healthy humans. J Appl Physiol 2017; 122(6): 1425-34.
[http://dx.doi.org/10.1152/japplphysiol.00694.2016] [PMID: 28336536]
[35]
Ekström M, Schiöler L, Grønseth R, et al. Absolute values of lung function explain the sex difference in breathlessness in the general population. Eur Respir J 2017; 49(5): 1602047.
[http://dx.doi.org/10.1183/13993003.02047-2016] [PMID: 28546280]
[36]
Nguyen HC, Nguyen MH, Do BN, et al. People with suspected COVID-19 symptoms were more likely depressed and had lower health-related quality of life: The potential benefit of health literacy. J Clin Med 2020; 9(4): 965.
[http://dx.doi.org/10.3390/jcm9040965] [PMID: 32244415]
[37]
Ravens-Sieberer U, Kaman A, Erhart M, Devine J, Schlack R, Otto C. Impact of the COVID-19 pandemic on quality of life and mental health in children and adolescents in Germany. Eur Child Adolesc Psychiatry 2021; 1-11.
[PMID: 33492480]
[38]
Cao J, Zheng X, Wei W, et al. Three-month outcomes of recovered COVID-19 patients: Prospective observational study. Ther Adv Respir Dis 2021; 15
[http://dx.doi.org/10.1177/17534666211009410] [PMID: 33878961]
[39]
Bardakci MI, Ozturk EN, Ozkarafakili MA, Ozkurt H, Yanc U, Yildiz Sevgi D. Evaluation of long-term radiological findings, pulmonary functions, and health-related quality of life in survivors of severe COVID-19. J Med Virol 2021; 93(9): 5574-81.
[http://dx.doi.org/10.1002/jmv.27101] [PMID: 34032292]
[40]
Aranda J, Oriol I, Martín M, et al. Long-term impact of COVID-19 associated acute respiratory distress syndrome. J Infect 2021; 83(5): 581-8.
[http://dx.doi.org/10.1016/j.jinf.2021.08.018] [PMID: 34400219]
[41]
Lin M, Huang L, Zheng D, Zhang L, Feng B, Liu Y, et al. Health-related quality of life of COVID-19 survivors at 6 months after hospital discharge: A cohort study. Res Square 2021.
[http://dx.doi.org/10.21203/rs.3.rs-176489/v1]
[42]
Stavem K, Ghanima W, Olsen MK, Gilboe HM, Einvik G. Prevalence and determinants of fatigue after covid-19 in non-hospitalized subjects: A population-based study. Int J Environ Res Public Health 2021; 18(4): 2030.
[http://dx.doi.org/10.3390/ijerph18042030] [PMID: 33669714]

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