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Current Enzyme Inhibition

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ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

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Review Article

Recent Advances in Enzyme Inhibition: A Pharmacological Review

Author(s): Kuldeep Singh*, Bharat Bhushan, Nidhi Mittal, Abhishek Kushwaha, Chandan Kumar Raikwar, Arun Kumar Sharma, Dilip Kumar Chanchal, Shivendra Kumar and Mohit Agrawal

Volume 20, Issue 1, 2024

Published on: 27 November, 2023

Page: [2 - 19] Pages: 18

DOI: 10.2174/0115734080271639231030093152

Price: $65

Abstract

Enzyme inhibition is a crucial mechanism for regulating biological processes and developing therapeutic interventions. This pharmacological review summarizes recent advances in enzyme inhibition, focusing on key developments and their implications for drug discovery and therapeutic strategies. It explains basic ideas, including the different kinds of inhibitors and how they work, and looks at recent advances in small-molecule inhibitor design, fragment-based drug discovery, and virtual screening techniques. The review also highlights the advances in targeting specific enzyme families, explaining the structural basis of enzyme-inhibitor interactions, optimizing inhibitor potency, selectivity, and pharmacokinetic properties, and new trends in enzyme inhibition. The clinical implications of recent advances in enzyme inhibition include the development of novel therapeutic agents for diseases like cancer, infectious diseases, and neurological disorders. The review addresses challenges and future directions in the field, such as optimizing drug safety, resistance mechanisms, and personalized medicine approaches. Overall, the insights provided in this review may inspire further research and collaborations to accelerate the translation of enzyme inhibitors into effective clinical treatments.

Keywords: Enzyme inhibition, drug discovery, novel strategies, various diseases, personalized medicine, resistance mechanisms, enzyme-inhibitor interactions.

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