Nanosuspension as a Novel Nanovehicle for Drug Delivery: A Recent Update on Patents and Therapeutic Applications

Title:Nanosuspension as a Novel Nanovehicle for Drug Delivery: A Recent Update on Patents and Therapeutic Applications

Volume: 14 Issue: 2

Author(s): Asha Rani, Ravinder Verma, Manish Kumar, Abhishek Tiwari, Varsha Tiwari, Shailendra Bhatt, Vineet Mittal and Deepak Kaushik*

Affiliation:

• Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India

Keywords: Nanosuspension, supercritical fluid method, high-pressure homogenization, nanojet, patent, hydrosol, precipitation method.

Abstract: Solubility is a critical factor for the therapeutic action of drugs and does not depend on the administration of routes. Various conventional methods are used to enhance the solubility of the drug, which show limited applicability. Nanotechnology is used to improve the solubility and bioavailability of drugs that belong to BCS classes II and IV. Nanosuspension is the dispersion of pure drug nanoparticles in aqueous with a minimum amount of surfactant, stabilizing the formula-tion. Various techniques, such as the bottom-up approach, dissocubes, nanopure, nanoedge, nano-jet process, supercritical fluid, dry co-grinding, milling media, and nanoprecipitation, have been used to formulate nanosuspension. Nanosuspension can be administered orally, inhalation, trans-dermal, ocular, injectable, topical, and pulmonary. To resolve the problem of solubility and stabil-ity, nanosuspension has received much attention because of its technical simplicity, cost-effectiveness, and ease of significant scale-up. Nanosuspension can control particle size surface charge properties and release the drug at specific sites at an optimal rate. Recently, more than 100 patents have been published on nanosuspension. This review article covers the different prepara-tion methods, formulation composition, marketed products, characterization, and recent patents on nanosuspension. The various benefits and evaluation of the parameters of nanosuspension are discussed briefly. This patent-based review will enhance the knowledge of control drug delivery and related patents on nanosuspension.

Cite this article as:

Rani Asha, Verma Ravinder, Kumar Manish, Tiwari Abhishek, Tiwari Varsha, Bhatt Shailendra, Mittal Vineet and Kaushik Deepak*, Nanosuspension as a Novel Nanovehicle for Drug Delivery: A Recent Update on Patents and Therapeutic Applications, Current Nanomedicine 2024; 14 (2) . https://dx.doi.org/10.2174/0124681873270131231023082115