Abstract
With the acceleration of people's pace of life, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world, which greatly threatens people's health and safety. Therefore, there is still an urgent need for higher-quality research and treatment in this area. Nuclear factor Red-2-related factor 2 (Nrf2), as a key transcription factor in the regulation of oxidative stress, plays an important role in inducing the body's antioxidant response. Although there are no approved drugs targeting Nrf2 to treat NAFLD so far, it is still of great significance to target Nrf2 to alleviate NAFLD. In recent years, studies have reported that many natural products treat NAFLD by acting on Nrf2 or Nrf2 pathways. This article reviews the role of Nrf2 in the pathogenesis of NAFLD and summarizes the currently reported natural products targeting Nrf2 or Nrf2 pathway for the treatment of NAFLD, which provides new ideas for the development of new NAFLD-related drugs.
Keywords: NAFLD, Nrf2, natural regulators, TG, FFA
Current Drug Delivery
Title:Mechanism of Action and Related Natural Regulators of Nrf2 in Nonalcoholic Fatty Liver Disease
Volume: 21 Issue: 10
Author(s): Wenfei Yu, Fengxia Zhang*, Decheng Meng, Xin Zhang, Yanan Feng, Guoliang Yin, Pengpeng Liang, Suwen Chen and Hongshuai Liu
Affiliation:
- Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China
Keywords: NAFLD, Nrf2, natural regulators, TG, FFA
Abstract: With the acceleration of people's pace of life, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world, which greatly threatens people's health and safety. Therefore, there is still an urgent need for higher-quality research and treatment in this area. Nuclear factor Red-2-related factor 2 (Nrf2), as a key transcription factor in the regulation of oxidative stress, plays an important role in inducing the body's antioxidant response. Although there are no approved drugs targeting Nrf2 to treat NAFLD so far, it is still of great significance to target Nrf2 to alleviate NAFLD. In recent years, studies have reported that many natural products treat NAFLD by acting on Nrf2 or Nrf2 pathways. This article reviews the role of Nrf2 in the pathogenesis of NAFLD and summarizes the currently reported natural products targeting Nrf2 or Nrf2 pathway for the treatment of NAFLD, which provides new ideas for the development of new NAFLD-related drugs.
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Cite this article as:
Yu Wenfei, Zhang Fengxia*, Meng Decheng, Zhang Xin, Feng Yanan, Yin Guoliang, Liang Pengpeng, Chen Suwen and Liu Hongshuai, Mechanism of Action and Related Natural Regulators of Nrf2 in Nonalcoholic Fatty Liver Disease, Current Drug Delivery 2024; 21 (10) . https://dx.doi.org/10.2174/0115672018260113231023064614
DOI https://dx.doi.org/10.2174/0115672018260113231023064614 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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